Amorolfine

Amorolfine

SCHEMBL933541

CCC(C)(C)c1ccc(CC(C)CN2CC(C)OC(C)C2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 1/20 1.00
CHRM1 P11229 1/20 1.00
DRD3 P35462 1/20 1.00
KCNH2 Q12809 1/20 1.00
SIGMAR1 Q99720 3/20 0.79
EBP Q15125 1/20 0.79
HRH3 Q9Y5N1 12/20 0.40
MAOB P27338 4/20 0.40
MAPK1 P28482 1/20 0.39
L3MBTL1 Q9Y468 2/20 0.38
ALDH1A1 P00352 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Amorolfine SCHEMBL8165433 1.00 ADORA3 (1.00) ADORA3CHRM1DRD3KCNH2SIGMAR1
Amorolfine SCHEMBL150666 1.00 ADORA3 (1.00) ADORA3CHRM1DRD3KCNH2SIGMAR1
Amorolfine SCHEMBL5579008 0.99 ADORA3 (0.97) ADORA3CHRM1DRD3KCNH2SIGMAR1
Amorolfine SCHEMBL36711 0.99 ADORA3 (0.97) ADORA3CHRM1DRD3KCNH2SIGMAR1
Amorolfine SCHEMBL1934866 0.99 ADORA3 (0.97) ADORA3CHRM1DRD3KCNH2SIGMAR1
Amorolfine SCHEMBL1649004 0.97 ADORA3 (0.95) ADORA3CHRM1DRD3KCNH2SIGMAR1
Amorolfine SCHEMBL3820874 0.95 ADORA3 (0.91) ADORA3CHRM1DRD3KCNH2SIGMAR1
Amorolfine SCHEMBL23111397 0.90 ADORA3 (0.81) ADORA3CHRM1DRD3KCNH2SIGMAR1
SCHEMBL19823129 0.90 ADORA3 (0.81) ADORA3CHRM1DRD3KCNH2SIGMAR1
SCHEMBL11164667 0.89 ADORA3 (0.80) ADORA3CHRM1DRD3KCNH2SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011003455-A1 METHOD FOR PRODUCING 4-(ALKYL)-1-(2-METHYL-3-(2,6-DIMETHYLMORPHOLINE)PROPYL) BENZOL COMPOUNDS CILAG AG (CH) 2011-01-13 WO claimed
EP-1143950-B1 TOPICAL APPLICATION PRODUCTS AGAINST ONYCHOMYCOSES BIOEQUAL AG (CH) 2005-03-09 EP claimed
EP-0389778-B1 Nail Varnish HOFFMANN LA ROCHE (CH) 1994-05-04 EP claimed
US-5120530-A Fungicides, water-insoluble cationic copolymers; chemical resistance, durability HOFFMANN-LA ROCHE INC. (US) 1992-06-09 US claimed
EP-0389778-A1 Nail Varnish F. HOFFMANN-LA ROCHE AG (CH) 1990-10-03 EP claimed
US-4202894-A AGRICULTURE HOFFMANN-LA ROCHE INC. (US) 1980-05-13 US claimed
US-11628145-B2 Coloured keratolytic nail lacquer OYSTERSHELL NV (BE) 2023-04-18 US disclosed
US-11147774-B2 Peelable nail lacquer OYSTERSHELL NV (BE) 2021-10-19 US disclosed
EP-3585358-B1 COLOURED KERATOLYTIC NAIL LACQUER OYSTERSHELL NV (BE) 2020-12-16 EP disclosed
EP-3585357-B1 PEELABLE NAIL LACQUER OYSTERSHELL NV (BE) 2020-12-09 EP disclosed
US-20200230088-A1 COLOURED KERATOLYTIC NAIL LACQUER OYSTERSHELL NV (BE) 2020-07-23 US disclosed
US-20200030249-A1 PEELABLE NAIL LACQUER OYSTERSHELL NV (BE) 2020-01-30 US disclosed
CN-110603032-A Strippable nail paint 牡蛎壳公司 2019-12-20 CN disclosed
EP-0389778-A1 Nail Varnish F. HOFFMANN-LA ROCHE AG (CH) 1990-10-03 EP disclosed
EP-0274147-A2 Process for preparing steroids NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) 1988-07-13 EP disclosed
EP-0024334-B1 MORPHOLINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, PHARMACEUTICAL PREPARATIONS CONTAINING THESE DERIVATIVES F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1983-07-20 EP disclosed
US-4384116-A Process for the preparation of morpholine and piperidine derivatives HOFFMANN-LA ROCHE INC. (US) 1983-05-17 US disclosed
EP-0008686-B1 SYNTHESIS OF PHENYL-PROPYL MORPHOLINE AND PIPERIDINE DERIVATIVES F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1983-04-20 EP disclosed
US-4202894-A AGRICULTURE HOFFMANN-LA ROCHE INC. (US) 1980-05-13 US disclosed
EP-0008686-A2 Synthesis of phenyl-propyl morpholine and piperidine derivatives F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1980-03-19 EP disclosed