Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Amorolfine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.91 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.91 |
| ▸ | DRD3 | P35462 | 1/20 | 0.91 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.91 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.72 |
| ▸ | EBP | Q15125 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.37 |
| ▸ | MAOB | P27338 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amorolfine SCHEMBL5579008 | 0.96 | ADORA3 (0.97) | ADORA3CHRM1DRD3KCNH2SIGMAR1 | |
| Amorolfine SCHEMBL1934866 | 0.96 | ADORA3 (0.97) | ADORA3CHRM1DRD3KCNH2SIGMAR1 | |
| Amorolfine SCHEMBL36711 | 0.96 | ADORA3 (0.97) | ADORA3CHRM1DRD3KCNH2SIGMAR1 | |
| Amorolfine SCHEMBL933541 | 0.95 | ADORA3 (1.00) | ADORA3CHRM1DRD3KCNH2SIGMAR1 | |
| Amorolfine SCHEMBL150666 | 0.95 | ADORA3 (1.00) | ADORA3CHRM1DRD3KCNH2SIGMAR1 | |
| Amorolfine SCHEMBL8165433 | 0.95 | ADORA3 (1.00) | ADORA3CHRM1DRD3KCNH2SIGMAR1 | |
| Amorolfine SCHEMBL1649004 | 0.93 | ADORA3 (0.95) | ADORA3CHRM1DRD3KCNH2SIGMAR1 | |
| Amorolfine SCHEMBL23111397 | 0.86 | ADORA3 (0.81) | ADORA3CHRM1DRD3KCNH2SIGMAR1 | |
| SCHEMBL19823129 | 0.85 | ADORA3 (0.81) | ADORA3CHRM1DRD3KCNH2SIGMAR1 | |
| Fenpropimorph SCHEMBL3710228 | 0.85 | SIGMAR1 (0.97) | ADORA3CHRM1DRD3KCNH2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097398-A1 | PROCESS OF PRODUCING AMOROLFINE | Galderma S.A. (CH) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008074887-A1 | PROCESS OF PRODUCING AMOROLFINE | GALDERMA S.A. (CH) | 2008-06-26 | — | — | WO | disclosed |