Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.47 |
| ▸ | MASP2 | O00187 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
| ▸ | CTSG | P08311 | 1/20 | 0.45 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.45 |
| ▸ | CMA1 | P23946 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9339505 | 0.92 | PPARG (0.47) | HDAC2HPGDHDAC6PRSS1CTSG | |
| SCHEMBL7306359 | 0.90 | PRSS1 (0.46) | HDAC1HDAC2HDAC3HPGDHDAC6 | |
| SCHEMBL7305313 | 0.88 | HDAC6 (0.49) | HDAC1HDAC2HDAC3HDAC6PRSS1 | |
| SCHEMBL7331153 | 0.87 | HDAC6 (0.53) | HDAC1HDAC2HDAC3HDAC6PRSS1 | |
| SCHEMBL7302006 | 0.84 | SYK (0.46) | HPGDPRSS1CTSGCTRB1CMA1 | |
| SCHEMBL9864590 | 0.84 | PAX8 (0.52) | NAMPTLMNA | |
| SCHEMBL7299446 | 0.84 | HRH4 (0.43) | TPSAB1MASP2HPGDPRSS1CTSG | |
| SCHEMBL9222240 | 0.83 | ACE (0.47) | HDAC1HDAC2HDAC3MASP2HPGD | |
| SCHEMBL7300795 | 0.83 | HRH4 (0.43) | MASP2HPGDPRSS1CTSGCTRB1 | |
| SCHEMBL23452597 | 0.83 | MASP2 (0.54) | HDAC1HDAC2HDAC3MASP2NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372486-B1 | Benzoic-acid phenylacetic-acid derivatives, their preparation and their use as medicines | HOFFMANN LA ROCHE (CH) | 1994-06-01 | — | — | EP | disclosed |
| US-5039805-A | Novel benzoic and phenylacetic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 1991-08-13 | — | — | US | disclosed |