Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Thiourea. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thiourea SCHEMBL28009945 | 0.97 | KDM4E (0.46) | — | |
| Sulfuric Acid SCHEMBL28217737 | 0.86 | KDM4E (0.53) | — | |
| Sulfuric Acid SCHEMBL5315249 | 0.86 | KDM4E (0.53) | — | |
| Sulfuric Acid SCHEMBL526776 | 0.86 | — | — | |
| Guanidine SCHEMBL5503970 | 0.86 | KDM4E (0.53) | — | |
| Guanidine SCHEMBL2136925 | 0.86 | — | — | |
| Guanidine SCHEMBL19458437 | 0.86 | KDM4E (0.53) | — | |
| Sulfuric Acid SCHEMBL27434030 | 0.84 | KDM4E (0.52) | — | |
| Thiourea SCHEMBL8576993 | 0.81 | BLM (0.43) | — | |
| Thiourea SCHEMBL7362564 | 0.79 | KDM4E (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103788164-A | Preparation method of fulvestrant | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD | 2014-05-14 | — | — | CN | claimed |
| CN-114685593-B | Fulvestrant preparation method and fulvestrant intermediate | 鲁南制药集团股份有限公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-104447447-B | Novel compound and methods for preparing and eliminating same | 天津孚音生物科技发展有限公司 | 2017-02-22 | — | — | CN | disclosed |
| CN-104447447-A | Novel compound and methods for preparing and eliminating same | TIANJIN FUYIN BIOTECHNOLOGY DEV CO LTD | 2015-03-25 | — | — | CN | disclosed |
| CN-104387435-A | New compound and preparation method and application thereof | TIANJIN FUYIN BIOTECHNOLOGY DEV CO LTD | 2015-03-04 | — | — | CN | disclosed |
| CN-103788164-A | Preparation method of fulvestrant | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD | 2014-05-14 | — | — | CN | disclosed |
| CN-103493799-A | Improved organ protection, preservation and recovery | HIBERNATION THERAPEUTICS LTD | 2014-01-08 | — | — | CN | disclosed |
| US-20120323001-A1 | BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2012-12-20 | — | — | US | disclosed |
| US-8278441-B2 | BACE inhibitors | ELI LILLY AND COMPANY (US) | 2012-10-02 | — | — | US | disclosed |
| EP-2451793-A1 | BACE INHIBITORS | Eli Lilly and Company (US) | 2012-05-16 | — | — | EP | disclosed |
| CN-102188705-A | Medicament composition containing bis cyclooctane derivatives | LIYAN WANG | 2011-09-21 | — | — | CN | disclosed |
| CN-102166215-A | Pharmaceutical composition containing piperazine derivatives | LIYAN WANG | 2011-08-31 | — | — | CN | disclosed |
| CN-102166357-A | Medicinal composition containing bicyclic aza-alkane derivative | LIYAN WANG | 2011-08-31 | — | — | CN | disclosed |
| US-20110009395-A1 | BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2011-01-13 | — | — | US | disclosed |
| WO-2011005738-A1 | BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2011-01-13 | — | — | WO | disclosed |
| EP-1526140-B1 | POTASSIUM-DEPENDENT SODIUM-CALCIUM EXCHANGER | ASTELLAS PHARMA INC (JP) | 2008-11-05 | — | — | EP | disclosed |
| US-4377693-A | 2-Chloro-4,5-disubstituted-thiazoles useful as herbicidal safeners | MONSANTO COMPANY (US) | 1983-03-22 | — | — | US | disclosed |
| EP-0027019-B1 | 2-CHLORO-4,5-DISUBSTITUTED-THIAZOLES, PROCESS FOR THEIR PREPARATION, USE AS ANTIDOTES AGAINST DAMAGE CAUSED BY HERBICIDES AND MIXTURES CONTAINING THEM | MONSANTO COMPANY (US) | 1983-02-16 | — | — | EP | disclosed |
| EP-0027019-A1 | 2-Chloro-4,5-disubstituted-thiazoles, process for their preparation, use as antidotes against damage caused by herbicides and mixtures containing them | MONSANTO COMPANY (US) | 1981-04-15 | — | — | EP | disclosed |