Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of Thiourea. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 4/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | NOS3 | P29474 | 2/20 | 0.33 |
| ▸ | NOS1 | P29475 | 2/20 | 0.33 |
| ▸ | NOS2 | P35228 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | NT5E | P21589 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanidine SCHEMBL8638683 | 0.88 | BLM (0.48) | BLMCYP2C19CYP2D6KDM4ENPSR1 | |
| Thiourea SCHEMBL2858681 | 0.85 | LMNA (0.40) | BLMCYP2C19CYP2D6KDM4ENPSR1 | |
| Thiourea SCHEMBL30543064 | 0.83 | CYP2C19 (0.39) | BLMCYP2C19CYP2D6KDM4ENPSR1 | |
| Thiourea SCHEMBL17819112 | 0.83 | CYP2C19 (0.39) | BLMCYP2C19CYP2D6KDM4ENPSR1 | |
| Thiourea SCHEMBL28835107 | 0.83 | CYP2C19 (0.39) | BLMCYP2C19CYP2D6KDM4ENPSR1 | |
| Thiourea SCHEMBL933625 | 0.81 | — | — | |
| Sulfuric Acid SCHEMBL28217737 | 0.81 | KDM4E (0.53) | BLMCYP2C19CYP2D6KDM4ENPSR1 | |
| Sulfuric Acid SCHEMBL5315249 | 0.81 | KDM4E (0.53) | BLMCYP2C19CYP2D6KDM4ENPSR1 | |
| Sulfuric Acid SCHEMBL526776 | 0.81 | — | — | |
| Sulfuric Acid SCHEMBL27434030 | 0.79 | KDM4E (0.52) | BLMCYP2C19CYP2D6KDM4ENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846407-A | Pyrite depressant useful in flotation separation | FUERSTENAU DOUGLAS W (US) | 1998-12-08 | — | — | US | claimed |
| US-5846407-A | Pyrite depressant useful in flotation separation | FUERSTENAU DOUGLAS W (US) | 1998-12-08 | — | — | US | disclosed |