Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.76 |
| ▸ | RAB9A | P51151 | 3/20 | 0.66 |
| ▸ | TP53 | P04637 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | AHR | P35869 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.59 |
| ▸ | RELA | Q04206 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11887682 | 0.78 | AHR (0.67) | GAALMNAAHRKMT2AALDH1A1 | |
| SCHEMBL23262624 | 0.77 | CCNK (0.74) | GAAAHRKMT2AMEN1MAPT | |
| SCHEMBL31681811 | 0.77 | CCNK (0.74) | GAAAHRKMT2AMEN1MAPT | |
| SCHEMBL19090370 | 0.75 | TDP1 (0.73) | RAB9ATP53TSHRLMNASMN1; SMN2 | |
| SCHEMBL11888631 | 0.75 | KMT2A (1.00) | GAAHSD17B10AHRKMT2ASMN1; SMN2 | |
| SCHEMBL23933096 | 0.74 | TDP1 (1.00) | GAARAB9ATP53TSHRLMNA | |
| SCHEMBL12035866 | 0.74 | RAB9A (0.59) | GAARAB9ATSHRLMNAAHR | |
| SCHEMBL2188598 | 0.74 | TDP1 (0.71) | RAB9ATP53TSHRLMNASMN1; SMN2 | |
| SCHEMBL2944497 | 0.74 | TDP1 (0.71) | RAB9ATP53TSHRLMNASMN1; SMN2 | |
| SCHEMBL29883158 | 0.74 | TDP1 (0.71) | RAB9ATP53TSHRLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011008475-A1 | OPTIONALLY SUBSTITUTED 2-(ARYLMETHYL, ARYLOXY OR ARYLTHIO) -N- PYRIDIN-2 -YL-ARYL ACETAMIDE OR 2, 2-BIS (ARYL) -N-PYRIDIN-2-YL ACETAMIDE COMPOUNDS AS MEDICAMENTS FOR THE TREATMENT OF EYE DISEASES | ALLERGAN, INC. (US) | 2011-01-20 | — | — | WO | claimed |