Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.47 |
| ▸ | PFKFB4 | Q16877 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 6/20 | 0.42 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9389077 | 0.86 | MAPT (0.48) | ALDH1A1NPC1MAPTRAB9AMEN1 | |
| SCHEMBL9383652 | 0.78 | HSD17B10 (0.42) | ALDH1A1NPC1MAPTRAB9AMEN1 | |
| SCHEMBL4957637 | 0.78 | MAPT (0.44) | L3MBTL1ALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL9337056 | 0.76 | KAT8 (0.48) | PFKFB3PFKFB4L3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL9337075 | 0.76 | KAT8 (0.48) | PFKFB3PFKFB4L3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL1121389 | 0.73 | NPC1 (0.50) | L3MBTL1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL28258783 | 0.72 | PPARA (0.54) | ALDH1A1NPC1MAPTRAB9AMEN1 | |
| SCHEMBL24962530 | 0.72 | SMN1; SMN2 (0.57) | MAPTMEN1KMT2APPARASMN1; SMN2 | |
| SCHEMBL30209129 | 0.72 | SMN1; SMN2 (0.57) | MAPTMEN1KMT2APPARASMN1; SMN2 | |
| SCHEMBL9385687 | 0.71 | MAPT (0.46) | CYP1A2CYP2C9NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533695-B1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER (US) | 1994-10-05 | — | — | EP | disclosed |
| US-5322847-A | Inhibit platelet activating factor, block leukotriene D4 receptors | PFIZER INC. (US) | 1994-06-21 | — | — | US | disclosed |
| EP-0533695-A1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY. | PFIZER (US) | 1993-03-31 | — | — | EP | disclosed |
| WO-1991017163-A1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER INC. (US) | 1991-11-14 | — | — | WO | disclosed |