Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | LIPA | P38571 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9339905 | 0.82 | HTT (0.60) | HTTNPSR1KMT2AMEN1LIPA | |
| SCHEMBL9339910 | 0.82 | HTT (0.60) | HTTNPSR1KMT2AMEN1LIPA | |
| SCHEMBL9817959 | 0.81 | CYP1A2 (0.63) | HTTNPSR1KMT2AMEN1LIPA | |
| SCHEMBL1587314 | 0.76 | CYP1A2 (0.67) | HTTNPSR1KMT2AMEN1LIPA | |
| SCHEMBL1587140 | 0.76 | CYP1A2 (0.67) | HTTNPSR1KMT2AMEN1LIPA | |
| SCHEMBL12316878 | 0.76 | KMT2A (0.82) | HTTNPSR1KMT2AMEN1ALDH1A1 | |
| SCHEMBL13953865 | 0.76 | KMT2A (0.69) | HTTNPSR1KMT2AMEN1LIPA | |
| SCHEMBL11529594 | 0.75 | HTT (0.61) | HTTNPSR1KMT2AMEN1LIPA | |
| SCHEMBL30673515 | 0.73 | CYP1A2 (0.67) | HTTNPSR1KMT2AMEN1LIPA | |
| SCHEMBL17078250 | 0.72 | LIPA (1.00) | HTTNPSR1KMT2AMEN1LIPA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0283147-B1 | Labile ketone derivatives of 3-substituted-1-alkylamino-2-propanols and their use as beta-adrenergic blockers | UNIV FLORIDA (US) | 1994-05-11 | — | — | EP | disclosed |
| US-5017618-A | Treatment Of Glaucoma | UNIVERSITY OF FLORIDA (US) | 1991-05-21 | — | — | US | disclosed |