Reversetriiodothyronine

Reversetriiodothyronine

SCHEMBL93386

N[C@H](Cc1ccc(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 1.00
KMT2A Q03164 5/20 1.00
PPARG P37231 4/20 1.00
NR1I2 O75469 2/20 1.00
AGTR2 P50052 1/20 1.00
BLM P54132 1/20 1.00
THRB P10828 9/20 0.70
THRA P10827 6/20 0.70
LMNA P02545 4/20 0.70
TTR P02766 2/20 0.70
ADORA3 P0DMS8 2/20 0.70
PDE4D Q08499 2/20 0.70
HSD17B10 Q99714 2/20 0.70
NR3C1 P04150 1/20 0.70
CYP1A2 P05177 1/20 0.70
HTR1A P08908 1/20 0.70
CYP2C9 P11712 1/20 0.70
TBXA2R P21731 1/20 0.70
NTSR1 P30989 1/20 0.70
HTR2B P41595 1/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Reverse Triiodothyronine SCHEMBL29354492 1.00 MEN1 (1.00) MEN1KMT2APPARGNR1I2AGTR2
Reversetriiodothyronine SCHEMBL429433 1.00 MEN1 (1.00) MEN1KMT2APPARGNR1I2AGTR2
Reverse Triiodothyronine SCHEMBL93385 1.00 MEN1 (1.00) MEN1KMT2APPARGNR1I2AGTR2
Reverse Triiodothyronine SCHEMBL2317251 0.99 MEN1 (0.97) MEN1KMT2APPARGNR1I2AGTR2
Reversetriiodothyronine SCHEMBL30812344 0.93 MEN1 (0.86) MEN1KMT2APPARGNR1I2AGTR2
Reversetriiodothyronine SCHEMBL30096343 0.92 MEN1 (0.84) MEN1KMT2APPARGNR1I2AGTR2
SCHEMBL14576176 0.91 MEN1 (0.84) MEN1KMT2APPARGNR1I2AGTR2
SCHEMBL14576177 0.91 MEN1 (0.84) MEN1KMT2APPARGNR1I2AGTR2
SCHEMBL14587190 0.90 MEN1 (0.82) MEN1KMT2APPARGNR1I2AGTR2
Rathyronine SCHEMBL10592340 0.88 THRB (0.78) MEN1KMT2APPARGNR1I2AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 263 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260097100-A1 CANCER TREATMENT BY INDUCTION OF TUMOR AND STEM CELL DIFFERENTIATION LATHAM KEITH ROGER (US) 2026-04-09 US claimed
CN-116410922-A Method for separating and differentiating animal fat source mesenchymal precursor cells 浙江大学 2023-07-11 CN claimed
US-9526701-B2 Sustained drug release and improved product stability using non-covalent particle coating methods JEROME STEVENS PHARMACEUTICALS, INC. 2016-12-27 US claimed
US-20040266877-A1 Liquid pharmaceutical compositions comprising thyroid hormones DICKINSON JEFFREY 2004-12-30 US claimed
EP-0732920-B1 THERAPEUTIC AGENTS CONTAINING THYROID HORMONES ABBOTT GMBH & CO KG (DE) 2003-10-29 EP claimed
US-20030130351-A1 Liquid pharmaceutical compositions comprising thyroid hormones KNOLL PHARMACEUTICAL COMPANY 2003-07-10 US claimed
US-6458842-B1 THYROID HORMONE OR HORMONES; FROM ABOUT 40% TO ABOUT 96% ETHANOL BY VOLUME; A PH ADJUSTING AGENT SO THAT THE MEASURED PH OF THE COMPOSITION IS FROM ABOUT 9 TO ABOUT 12; AND FROM ABOUT 4% TO ABOUT 50% WATER BY VOLUME; FOR DELIVERY KNOLL AKTIENGESELLSCHAFT (DE) 2002-10-01 US claimed
EP-0742714-B1 LIQUID PHARMACEUTICAL COMPOSITIONS COMPRISING THYROID HORMONES KNOLL AG (DE) 2001-03-28 EP claimed
EP-0751769-A4 MEDICAL TREATMENT USING THYROID HORMONES UNIV MICHIGAN (US) 1998-05-27 EP claimed
US-5753254-A INCLUDES DISINTEGRATING AGENT, FLAVORING AGENT, AND LUBRICATING AGENT KNOLL AKTIENGESELLSCHAFT (DE) 1998-05-19 US claimed
EP-0751769-A1 MEDICAL TREATMENT USING THYROID HORMONES The Regents of The University of Michigan (US) 1997-01-08 EP claimed
WO-1995000135-A1 MEDICAL TREATMENT USING THYROID HORMONES THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 1995-01-05 WO claimed
EP-0163122-B1 METHOD FOR THE DETERMINATION OF FREE SUBSTANCES IN BIOLOGICAL FLUIDS Henning Berlin GmbH Chemie- und Pharmawerk (DE) 1992-03-04 EP claimed
US-12637697-B2 Compositions and methods for generating physiological X chromosome inactivation CHILDREN'S MEDICAL CENTER CORPORATION (US) 2026-05-26 US disclosed
US-20260097100-A1 CANCER TREATMENT BY INDUCTION OF TUMOR AND STEM CELL DIFFERENTIATION LATHAM KEITH ROGER (US) 2026-04-09 US disclosed
US-20260043008-A1 CELL CRYOPRESERVATIVE FORMULATIONS AND METHODS OF USE ASTELLAS INST FOR REGENERATIVE MEDICINE (US) 2026-02-12 US disclosed
EP-0287653-A4 HORMONE RECEPTOR COMPOSITIONS AND METHODS. SALK INST FOR BIOLOGICAL STUDI (US) 1989-06-13 EP disclosed
EP-0287653-A1 HORMONE RECEPTOR COMPOSITIONS AND METHODS THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 1988-10-26 EP disclosed
WO-1988003168-A1 HORMONE RECEPTOR COMPOSITIONS AND METHODS THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 1988-05-05 WO disclosed
US-4490221-A Process for preparing iodothyronines and iodothyroacetic acids by electrochemical reduction at controlled potential SPIRAL SOCIETE A RESPONSABILITE LIMITEE DITE (FR) 1984-12-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260043008-A1 CELL CRYOPRESERVATIVE FORMULATIONS AND METHODS OF USE SLC2A3, CASP3, BCL2 MEN1 4703/4885KMT2A 4698/4885PPARG 1687/4885
US-12637697-B2 Compositions and methods for generating physiological X chromosome inactivation KDM6B, KDM1B, KDM6A MEN1 4079/4885KMT2A 14/4885PPARG 4374/4885
US-20260097100-A1 CANCER TREATMENT BY INDUCTION OF TUMOR AND STEM CELL DIFFERENTIATION TPO, TSHR, THRB MEN1 2848/4885KMT2A 4147/4885PPARG 464/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.