Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.40 |
| ▸ | GSR | P00390 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 5/20 | 0.37 |
| ▸ | NOS3 | P29474 | 3/20 | 0.37 |
| ▸ | NOS1 | P29475 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ARG2 | P78540 | 4/20 | 0.37 |
| ▸ | ARG1 | P05089 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9338676 | 1.00 | OTC (0.40) | OTCGSRNOS2NOS3NOS1 | |
| SCHEMBL8619137 | 0.91 | L3MBTL1 (0.39) | GSRKMT2AL3MBTL1BLMLMNA | |
| Valeric Acid SCHEMBL9334545 | 0.89 | METAP1 (0.41) | GSRMETAP1BLMLMNACYP1A2 | |
| Valeric Acid SCHEMBL9336479 | 0.89 | METAP1 (0.41) | GSRMETAP1BLMLMNACYP1A2 | |
| SCHEMBL8618018 | 0.81 | L3MBTL1 (0.36) | GSRNOS2NOS3NOS1KMT2A | |
| SCHEMBL13585340 | 0.78 | EPHX2 (0.45) | TSHR | |
| SCHEMBL13585343 | 0.78 | EPHX2 (0.45) | TSHR | |
| SCHEMBL2235591 | 0.77 | METAP1 (0.50) | OTCGSRNOS2NOS3NOS1 | |
| SCHEMBL2235588 | 0.77 | METAP1 (0.50) | OTCGSRNOS2NOS3NOS1 | |
| SCHEMBL7597963 | 0.76 | OTC (0.47) | OTCGSRNOS2NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5318992-A | Administering for the treatment of hypotensive conditions and shock | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-06-07 | — | — | US | disclosed |