Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.50 |
| ▸ | GSR | P00390 | 2/20 | 0.47 |
| ▸ | OTC | P00480 | 1/20 | 0.46 |
| ▸ | NOS2 | P35228 | 6/20 | 0.43 |
| ▸ | NOS1 | P29475 | 4/20 | 0.43 |
| ▸ | NOS3 | P29474 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ARG2 | P78540 | 4/20 | 0.43 |
| ▸ | ARG1 | P05089 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | GRM8 | O00222 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2235588 | 1.00 | METAP1 (0.50) | METAP1GSROTCNOS2NOS1 | |
| SCHEMBL2240987 | 0.95 | GSR (0.50) | METAP1GSROTCNOS2NOS1 | |
| SCHEMBL2240984 | 0.95 | GSR (0.50) | METAP1GSROTCNOS2NOS1 | |
| SCHEMBL2235419 | 0.89 | METAP1 (0.45) | METAP1GSROTCNOS2NOS1 | |
| SCHEMBL2235415 | 0.89 | METAP1 (0.45) | METAP1GSROTCNOS2NOS1 | |
| SCHEMBL2263297 | 0.86 | GSR (0.46) | METAP1GSROTCARG2ARG1 | |
| SCHEMBL2263302 | 0.86 | GSR (0.46) | METAP1GSROTCARG2ARG1 | |
| SCHEMBL2092242 | 0.84 | OTC (0.40) | METAP1GSROTCNOS2CYP2C19 | |
| SCHEMBL9338666 | 0.77 | OTC (0.40) | METAP1GSROTCNOS2NOS1 | |
| SCHEMBL7597963 | 0.77 | OTC (0.47) | METAP1GSROTCNOS2NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11753446-B2 | Beta-hairpin peptidomimetics | POLYPHOR AG (CH) | 2023-09-12 | — | — | US | disclosed |
| US-11629171-B2 | Beta-hairpin peptidomimetics | SPEXIS AG (CH) | 2023-04-18 | — | — | US | disclosed |
| CN-115093463-A | Beta-hairpin peptidomimetics | 波利弗尔股份公司 | 2022-09-23 | — | — | CN | disclosed |
| EP-3201219-B1 | BETA-HAIRPIN PEPTIDOMIMETICS | POLYPHOR AG (CH) | 2021-11-17 | — | — | EP | disclosed |
| EP-3201218-B1 | BETA-HAIRPIN PEPTIDOMIMETICS | POLYPHOR AG (CH) | 2021-11-03 | — | — | EP | disclosed |
| CN-105324390-B | Beta-hairpin peptidomimetics | 波利弗尔股份公司 | 2021-10-19 | — | — | CN | disclosed |
| US-20210284693-A1 | BETA-HAIRPIN PEPTIDOMIMETICS | SPEXIS AG (CH) | 2021-09-16 | — | — | US | disclosed |
| CN-105849119-B | Beta-hairpin peptidomimetics | 波利弗尔股份公司 | 2021-01-19 | — | — | CN | disclosed |
| US-10829520-B2 | Beta-hairpin peptidomimetics | POLYPHOR AG (CH) | 2020-11-10 | — | — | US | disclosed |
| CN-111770932-A | Beta-hairpin peptidomimetics | 波利弗尔股份公司 | 2020-10-13 | — | — | CN | disclosed |
| US-9109009-B2 | Template-fixed peptidomimetics with CXCR7 modulating activity | POLYPHOR AG (CH) | 2015-08-18 | — | — | US | disclosed |
| WO-2014161781-A1 | BETA-HAIRPIN PEPTIDOMIMETICS | POLYPHOR AG (CH) | 2014-10-09 | — | — | WO | disclosed |
| WO-2014161782-A1 | BETA-HAIRPIN PEPTIDOMIMETICS | POLYPHOR AG (CH) | 2014-10-09 | — | — | WO | disclosed |
| US-20140287986-A1 | TEMPLATE-FIXED PEPTIDOMIMETICS AS INHIBITORS OF FPR1 | POLYPHOR AG (CH) | 2014-09-25 | — | — | US | disclosed |
| EP-2764010-A1 | TEMPLATE -FIXED PEPTIDOMIMETICS AS INHIBITORS OF FPR1 | Polyphor Ag (CH) | 2014-08-13 | — | — | EP | disclosed |
| US-20130225506-A1 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH CXCR7 MODULATING ACTIVITY | POLYPHOR AG (CH) | 2013-08-29 | — | — | US | disclosed |
| WO-2013050346-A1 | TEMPLATE -FIXED PEPTIDOMIMETICS AS INHIBITORS OF FPR1 | POLYPHOR AG (CH) | 2013-04-11 | — | — | WO | disclosed |
| CN-102844327-A | Template-fixed peptidomimetics with CXCR7 modulatory activity | POLYPHOR AG | 2012-12-26 | — | — | CN | disclosed |
| EP-2531520-A1 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH CXCR7 MODULATING ACTIVITY | Polyphor AG (CH) | 2012-12-12 | — | — | EP | disclosed |
| WO-2011095607-A1 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH CXCR7 MODULATING ACTIVITY | POLYPHOR AG (CH) | 2011-08-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140287986-A1 | TEMPLATE-FIXED PEPTIDOMIMETICS AS INHIBITORS OF FPR1 | FPR1, FPR3, FPR2 | METAP1 232/4885GSR 3282/4885OTC 4665/4885 |
| US-11629171-B2 | Beta-hairpin peptidomimetics | POLL, POLQ, HBZ | METAP1 709/4885GSR 2063/4885OTC 2440/4885 |
| US-20130225506-A1 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH CXCR7 MODULATING ACTIVITY | CXCR1, CXCL12, CXCR6 | METAP1 2007/4885GSR 2635/4885OTC 3134/4885 |
| US-20210284693-A1 | BETA-HAIRPIN PEPTIDOMIMETICS | POLL, POLQ, POLM | METAP1 695/4885GSR 2471/4885OTC 1843/4885 |
| US-10829520-B2 | Beta-hairpin peptidomimetics | POLQ, POLL, POLM | METAP1 594/4885GSR 2385/4885OTC 2966/4885 |
| US-11753446-B2 | Beta-hairpin peptidomimetics | POLL, BACE1, C1S | METAP1 217/4885GSR 3549/4885OTC 3842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.