Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 8/20 | 0.36 |
| ▸ | CYSLTR2 | Q9NS75 | 7/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.32 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9338940 | 0.89 | MAPT (0.42) | CYSLTR1CYSLTR2HSD17B10MAPTNPC1 | |
| SCHEMBL9339062 | 0.87 | CYSLTR1 (0.38) | CYSLTR1CYSLTR2MAPTNPC1RAB9A | |
| SCHEMBL9339068 | 0.77 | KAT8 (0.44) | HSD17B10MAPTNPC1RAB9ADYRK1A | |
| SCHEMBL9387728 | 0.77 | HSD17B10 (0.43) | HSD17B10MAPTNPC1RAB9APTGER4 | |
| SCHEMBL9383652 | 0.76 | HSD17B10 (0.42) | HSD17B10MAPTNPC1RAB9ATRPV1 | |
| SCHEMBL9339006 | 0.73 | MAPT (0.44) | MAPTNPC1RAB9APTGER4DYRK1A | |
| SCHEMBL9389077 | 0.73 | MAPT (0.48) | HSD17B10MAPTNPC1RAB9APTGER4 | |
| SCHEMBL9385687 | 0.72 | MAPT (0.46) | CYSLTR1CYSLTR2HSD17B10MAPTNPC1 | |
| SCHEMBL9388341 | 0.72 | MAPT (0.41) | MAPTNPC1RAB9APTGER4DYRK1A | |
| SCHEMBL9337325 | 0.72 | AHR (0.46) | DYRK1AHCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533695-B1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER (US) | 1994-10-05 | — | — | EP | disclosed |
| US-5322847-A | Inhibit platelet activating factor, block leukotriene D4 receptors | PFIZER INC. (US) | 1994-06-21 | — | — | US | disclosed |
| WO-1991017163-A1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER INC. (US) | 1991-11-14 | — | — | WO | disclosed |