Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9343034 | 0.88 | MEN1 (0.52) | KDM4EALDH1A1LMNAKMT2AGAA | |
| SCHEMBL9339094 | 0.85 | ALDH1A1 (0.52) | ALDH1A1LMNAKMT2ATDP1POLB | |
| SCHEMBL27380810 | 0.84 | KDM4E (0.49) | KDM4EALDH1A1CYP19A1KMT2ATDP1 | |
| SCHEMBL9343014 | 0.82 | KMT2A (0.51) | KDM4ELMNAKMT2AGAAEPHX2 | |
| SCHEMBL9339739 | 0.82 | EPHX2 (0.54) | KDM4EALDH1A1LMNAKMT2AGAA | |
| SCHEMBL9339122 | 0.81 | DRD2 (0.48) | HDAC1ALOX15 | |
| SCHEMBL9341043 | 0.81 | KMT2A (0.54) | KDM4ELMNAKMT2APOLBALOX15 | |
| SCHEMBL9339176 | 0.80 | KMT2A (0.54) | KDM4EALDH1A1LMNAKMT2AGAA | |
| SCHEMBL9339746 | 0.79 | SMN1; SMN2 (0.53) | ALDH1A1LMNAKMT2ATDP1EPHX2 | |
| SCHEMBL28887010 | 0.79 | GAA (0.53) | KDM4EALDH1A1LMNAKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5360808-A | Cardiovascular disorders, antispasmodic agents, hypotensive disorders, brains, anticonvulsants and antiepileptics | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-11-01 | — | — | US | disclosed |
| EP-0556738-A1 | Pyridinylcarbonylaminoalkyl-dihydro-oxo-pyridines, their production and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-08-25 | — | — | EP | disclosed |
| CN-1075480-A | New aryl carbonylamino alkyl-dihydro-oxo pyridine compounds and production thereof and application | HOECHST AG (US) | 1993-08-25 | — | — | CN | disclosed |