Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CDC25A | P30304 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | CTRC | Q99895 | 1/20 | 0.36 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4463965 | 0.71 | CASP1 (0.40) | ALDH1A1HSD17B10HPGDKDM4ETSHR | |
| SCHEMBL4558471 | 0.69 | ALDH1A1 (0.49) | ALDH1A1HSD17B10HPGDKDM4ETSHR | |
| SCHEMBL9532751 | 0.68 | AGTR1 (0.50) | — | |
| SCHEMBL2461497 | 0.67 | ALDH1A1 (0.56) | ALDH1A1HSD17B10HPGDCDC25A | |
| SCHEMBL27925319 | 0.67 | TYR (0.61) | ALDH1A1HSD17B10HPGDTSHRPOLB | |
| SCHEMBL9190210 | 0.67 | ALDH1A1 (0.66) | ALDH1A1HSD17B10HPGDKDM4ETSHR | |
| SCHEMBL7226330 | 0.65 | ALDH1A1 (0.56) | ALDH1A1HSD17B10HPGDKDM4ETSHR | |
| SCHEMBL20856808 | 0.64 | ALDH1A1 (0.51) | ALDH1A1HSD17B10HPGDPTGS2 | |
| SCHEMBL1445637 | 0.63 | ALDH1A1 (1.00) | ALDH1A1HSD17B10HPGDKDM4ETSHR | |
| SCHEMBL7341368 | 0.63 | ALDH1A1 (0.58) | ALDH1A1HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332750-A | Treatment of hypertension, aldosteronism, cardiac insufficienc y | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1994-07-26 | — | — | US | disclosed |