Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.75 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.69 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9339366 | 0.99 | PPARG (0.75) | PPARGAGTR1AGTR2 | |
| SCHEMBL9336732 | 0.96 | AGTR1 (0.75) | PPARGAGTR1AGTR2 | |
| SCHEMBL9336993 | 0.93 | PPARG (0.79) | PPARG | |
| SCHEMBL8396598 | 0.92 | AGTR1 (0.79) | PPARGAGTR1AGTR2 | |
| SCHEMBL9335583 | 0.90 | PPARG (0.75) | PPARGAGTR1AGTR2 | |
| SCHEMBL9335223 | 0.90 | PPARG (0.75) | PPARGAGTR1AGTR2 | |
| SCHEMBL9335587 | 0.90 | PPARG (0.75) | PPARGAGTR1AGTR2 | |
| SCHEMBL9335843 | 0.90 | PPARG (0.75) | PPARGAGTR1AGTR2 | |
| SCHEMBL9339019 | 0.90 | PPARG (0.75) | PPARGAGTR1AGTR2 | |
| SCHEMBL9335483 | 0.90 | PPARG (0.75) | PPARGAGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0432737-A1 | Cycloheptimidazolone compounds as angiotensin II antagonists for control of hypertension | G.D. Searle & Co. (US) | 1991-06-19 | — | — | EP | claimed |
| US-5281615-A | Hypotensive agents | G. D. SEARLE & CO. (US) | 1994-01-25 | — | — | US | disclosed |
| US-5104891-A | CYCLOHEPTIMIDAZOLONE COMPOUNDS AS ANGIOTENSIN II ANTAGONISTS FOR CONTROL OF HYPERTENSION | G. D. SEARLE & CO. (US) | 1992-04-14 | — | — | US | disclosed |
| EP-0432737-A1 | Cycloheptimidazolone compounds as angiotensin II antagonists for control of hypertension | G.D. Searle & Co. (US) | 1991-06-19 | — | — | EP | disclosed |