Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.54 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | WNT3A | P56704 | 1/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL934604 | 0.86 | EPHX2 (0.63) | LMNAMAPTKMT2ACYP1A2CYP3A4 | |
| SCHEMBL2570995 | 0.84 | LMNA (0.62) | LMNAMKNK1MKNK2POLBCYP2A6 | |
| SCHEMBL31321081 | 0.83 | MAPT (0.69) | LMNAPOLBMAPTALDH1A1GAA | |
| SCHEMBL10023 | 0.83 | MAPT (0.69) | LMNAPOLBMAPTALDH1A1GAA | |
| SCHEMBL933899 | 0.83 | PPID (0.58) | LMNAPOLBMAPTALDH1A1GAA | |
| SCHEMBL13652538 | 0.83 | LMNA (0.70) | LMNAALDH1A1TRPV1GAAMEN1 | |
| SCHEMBL27823146 | 0.82 | RECQL (0.69) | LMNAMKNK1MKNK2POLBCYP2A6 | |
| SCHEMBL24895800 | 0.79 | SMN1; SMN2 (0.64) | POLBMAPTALDH1A1WNT3AMEN1 | |
| SCHEMBL2334562 | 0.79 | POLB (0.55) | LMNAMKNK1MKNK2POLBCYP2A6 | |
| SCHEMBL246648 | 0.79 | MMP13 (0.74) | LMNAMKNK1MKNK2TRPV1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011006935-A2 | TETRAZOLE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-01-20 | — | — | WO | disclosed |