Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA2 | P47869 | 7/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 7/20 | 0.36 |
| ▸ | GABRP | O00591 | 3/20 | 0.36 |
| ▸ | GABRD | O14764 | 3/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.36 |
| ▸ | GABRE | P78334 | 3/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.36 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.36 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.36 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9341586 | 0.90 | KDM5B (0.37) | GABRB3ABL1BCRKDM5BLMNA | |
| SCHEMBL9723106 | 0.90 | GABRA2 (0.40) | GABRA2GABRB2GABRB3GABRPGABRD | |
| SCHEMBL9340316 | 0.85 | GABRA2 (0.37) | GABRA2GABRB2GABRB3GABRPGABRD | |
| SCHEMBL9723095 | 0.85 | HCAR1 (0.36) | GABRB3KDM5BALDH1A1 | |
| SCHEMBL9723104 | 0.85 | GABRA2 (0.37) | GABRA2GABRB2GABRB3GABRPGABRD | |
| SCHEMBL9731349 | 0.85 | KDM5B (0.34) | GABRB3KDM5BALDH1A1 | |
| SCHEMBL9339471 | 0.84 | GABRA2 (0.36) | GABRA2GABRB2GABRB3GABRPGABRD | |
| SCHEMBL9723071 | 0.83 | NPSR1 (0.36) | NPSR1KDM5BMEN1KMT2AL3MBTL1 | |
| SCHEMBL9723133 | 0.83 | DDR1 (0.34) | NPSR1KDM5BMEN1KMT2AL3MBTL1 | |
| SCHEMBL9593992 | 0.82 | GABRA2 (0.36) | GABRA2GABRB2GABRB3GABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0338686-B1 | Pyrimidinone derivatives | ZENECA LTD (GB) | 1994-06-22 | — | — | EP | disclosed |
| US-5149810-A | Chemical intermediates for insecticides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-09-22 | — | — | US | disclosed |
| US-5077297-A | Insecticides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-12-31 | — | — | US | disclosed |
| EP-0338686-A2 | Pyrimidinone derivatives | ZENECA LIMITED (GB) | 1989-10-25 | — | — | EP | disclosed |