Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.36 |
| ▸ | GABRE | P78334 | 1/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.36 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL668872 | 0.84 | PDE2A (0.41) | ALDH1A1POLBPLAUKDM4ESMN1; SMN2 | |
| Fluoride Ion SCHEMBL10713269 | 0.79 | PDE2A (0.38) | ALDH1A1POLBPLAUKDM4ESMN1; SMN2 | |
| SCHEMBL22366856 | 0.79 | GABRB3 (0.44) | ALDH1A1NOTUMPOLBPLAUKDM4E | |
| SCHEMBL1531168 | 0.77 | PDE2A (0.37) | ALDH1A1POLBPLAUKDM4ESMN1; SMN2 | |
| SCHEMBL13326020 | 0.77 | PDE2A (0.33) | PDE2A | |
| SCHEMBL978300 | 0.77 | CA1 (0.44) | ALDH1A1NOTUMPOLBPLAUKDM4E | |
| SCHEMBL30777281 | 0.77 | CA1 (0.44) | ALDH1A1NOTUMPOLBPLAUKDM4E | |
| SCHEMBL10262533 | 0.76 | PDE2A (0.40) | ALDH1A1GABRA2GABRB2GABRPGABRD | |
| SCHEMBL24597111 | 0.74 | PTPN5 (0.41) | ALDH1A1KDM4EHPGDTSHRGAA | |
| SCHEMBL2331553 | 0.74 | PDE2A (0.39) | ALDH1A1POLBPLAUKDM4EPDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0338686-B1 | Pyrimidinone derivatives | ZENECA LTD (GB) | 1994-06-22 | — | — | EP | disclosed |
| US-5149810-A | Chemical intermediates for insecticides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-09-22 | — | — | US | disclosed |
| US-5077297-A | Insecticides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-12-31 | — | — | US | disclosed |
| CN-1037705-A | The preparation method of new pyrimidone derivatives | ICI PLC (GB) | 1989-12-06 | — | — | CN | disclosed |
| EP-0338686-A2 | Pyrimidinone derivatives | ZENECA LIMITED (GB) | 1989-10-25 | — | — | EP | disclosed |