Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRZ1 | P23471 | 3/20 | 0.75 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.60 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.60 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13968784 | 0.84 | PTPRZ1 (0.66) | PTPRZ1EPHX2NR1H4PTPN1MAPT | |
| SCHEMBL11081323 | 0.84 | PTPRZ1 (0.69) | PTPRZ1EPHX2NR1H4PTPN1MAPT | |
| SCHEMBL935245 | 0.82 | PTPRZ1 (0.52) | PTPRZ1EPHX2NR1H4MAPTATM | |
| SCHEMBL22059617 | 0.80 | LMNA (0.56) | PTPRZ1EPHX2NR1H4MAPTPOLB | |
| SCHEMBL22060051 | 0.80 | PTPRZ1 (0.64) | PTPRZ1EPHX2NR1H4PTPN1MAPT | |
| SCHEMBL934145 | 0.79 | HDAC3 (0.60) | EPHX2POLBNAMPTCYP1A2CYP2C9 | |
| SCHEMBL2713728 | 0.77 | EPHX2 (0.55) | PTPRZ1EPHX2NR1H4PTPN1NAMPT | |
| SCHEMBL1709338 | 0.76 | HPGD (0.70) | POLBHPGDLMNA | |
| SCHEMBL6001754 | 0.76 | EPHX2 (0.73) | PTPRZ1EPHX2NR1H4PTPN1MAPT | |
| SCHEMBL826020 | 0.76 | KMT2A (0.53) | HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011006935-A2 | TETRAZOLE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-01-20 | — | — | WO | disclosed |