Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylamine SCHEMBL9341709 | 0.90 | SLC6A4 (0.36) | TP53CCR1ALDH1A1KDM4EMEN1 | |
| Dimethylamine SCHEMBL9337974 | 0.89 | ALDH1A1 (0.40) | ALDH1A1KDM4EMEN1KMT2ACYP1A2 | |
| SCHEMBL9339474 | 0.89 | TP53 (0.38) | TP53CCR1ALDH1A1KDM4EMEN1 | |
| SCHEMBL9342579 | 0.79 | ALDH1A1 (0.33) | ALDH1A1KDM4EMEN1KMT2ACYP1A2 | |
| SCHEMBL9339467 | 0.76 | KMT2A (0.33) | TP53ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL9338360 | 0.76 | SLC6A4 (0.36) | TP53ALDH1A1KDM4EMEN1KMT2A | |
| Dimethylamine SCHEMBL9337652 | 0.73 | MEN1 (0.41) | CCR1ALDH1A1KDM4EMEN1KMT2A | |
| Dimethylamine SCHEMBL9337624 | 0.72 | TSHR (0.40) | ALDH1A1L3MBTL1CYP2D6MAPTSMN1; SMN2 | |
| Dimethylamine SCHEMBL9341629 | 0.72 | SLC6A4 (0.46) | ALDH1A1CYP3A4L3MBTL1CYP2D6 | |
| SCHEMBL9337833 | 0.72 | KMT2A (0.34) | TP53ALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0450995-B1 | New propanamines, their pharmacological properties and their therapeutical applications, notably as anti-diarrhoea agents | JOUVEINAL SA (FR) | 1994-06-08 | — | — | EP | disclosed |
| US-5143938-A | PROPANAMINES, THEIR PHARMACOLOGICAL PROPERTIES AND THEIR APPLICATION FOR THERAPEUTIC IN PARTICULAR ANTIDIARRHEAL, PURPOSES | JOUVEINAL S.A. (FR) | 1992-09-01 | — | — | US | disclosed |
| EP-0450995-A1 | New propanamines, their pharmacological properties and their therapeutical applications, notably as anti-diarrhoea agents | JOUVEINAL S.A. (FR) | 1991-10-09 | — | — | EP | disclosed |