Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.35 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylamine SCHEMBL9339744 | 0.89 | TP53 (0.40) | ALDH1A1MEN1KMT2AL3MBTL1KDM4E | |
| Dimethylamine SCHEMBL9341709 | 0.85 | SLC6A4 (0.36) | ALDH1A1MEN1KMT2AL3MBTL1KDM4E | |
| Dimethylamine SCHEMBL9337624 | 0.84 | TSHR (0.40) | ALDH1A1L3MBTL1MAPTMAPK1SMN1; SMN2 | |
| Dimethylamine SCHEMBL9337652 | 0.83 | MEN1 (0.41) | ALDH1A1MEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL9342579 | 0.79 | ALDH1A1 (0.33) | ALDH1A1MEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL9339474 | 0.78 | TP53 (0.38) | ALDH1A1MEN1KMT2AL3MBTL1KDM4E | |
| Dimethylamine SCHEMBL9341629 | 0.78 | SLC6A4 (0.46) | ALDH1A1L3MBTL1CYP3A4TSHRCYP2D6 | |
| SCHEMBL9338360 | 0.76 | SLC6A4 (0.36) | ALDH1A1MEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL9338202 | 0.75 | SLC6A4 (0.38) | ALDH1A1MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL9337972 | 0.70 | MAPT (0.41) | ALDH1A1MEN1KMT2AL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0450995-B1 | New propanamines, their pharmacological properties and their therapeutical applications, notably as anti-diarrhoea agents | JOUVEINAL SA (FR) | 1994-06-08 | — | — | EP | disclosed |
| US-5236947-A | Side effect reduction | JOUVEINAL S.A. (FR) | 1993-08-17 | — | — | US | disclosed |
| US-5143938-A | PROPANAMINES, THEIR PHARMACOLOGICAL PROPERTIES AND THEIR APPLICATION FOR THERAPEUTIC IN PARTICULAR ANTIDIARRHEAL, PURPOSES | JOUVEINAL S.A. (FR) | 1992-09-01 | — | — | US | disclosed |
| EP-0450995-A1 | New propanamines, their pharmacological properties and their therapeutical applications, notably as anti-diarrhoea agents | JOUVEINAL S.A. (FR) | 1991-10-09 | — | — | EP | disclosed |