Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.32 |
| ▸ | TUBB | P07437 | 1/20 | 0.32 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.32 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.32 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.32 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.32 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9339474 | 0.91 | TP53 (0.38) | ALDH1A1CYP1A2CYP3A4CYP2C19KDM4E | |
| SCHEMBL9338360 | 0.88 | SLC6A4 (0.36) | ALDH1A1CYP1A2CYP3A4CYP2C19KDM4E | |
| Dimethylamine SCHEMBL9339744 | 0.79 | TP53 (0.40) | ALDH1A1CYP1A2CYP3A4CYP2C19KDM4E | |
| Dimethylamine SCHEMBL9337974 | 0.79 | ALDH1A1 (0.40) | ALDH1A1CYP1A2CYP3A4CYP2C19KDM4E | |
| SCHEMBL9338202 | 0.78 | SLC6A4 (0.38) | ALDH1A1CYP1A2CYP3A4CYP2C19MEN1 | |
| Dimethylamine SCHEMBL9341709 | 0.76 | SLC6A4 (0.36) | ALDH1A1CYP1A2CYP3A4CYP2C19KDM4E | |
| SCHEMBL9339653 | 0.74 | HTR2A (0.45) | CYP1A2CYP3A4CYP2C19MEN1KMT2A | |
| Dimethylamine SCHEMBL9337652 | 0.71 | MEN1 (0.41) | ALDH1A1CYP1A2CYP3A4CYP2C19KDM4E | |
| SCHEMBL9337972 | 0.69 | MAPT (0.41) | ALDH1A1CYP1A2CYP3A4CYP2C19KDM4E | |
| SCHEMBL9341939 | 0.69 | SLC6A4 (0.45) | CYP3A4CYP2D6SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0450995-B1 | New propanamines, their pharmacological properties and their therapeutical applications, notably as anti-diarrhoea agents | JOUVEINAL SA (FR) | 1994-06-08 | — | — | EP | disclosed |
| US-5143938-A | PROPANAMINES, THEIR PHARMACOLOGICAL PROPERTIES AND THEIR APPLICATION FOR THERAPEUTIC IN PARTICULAR ANTIDIARRHEAL, PURPOSES | JOUVEINAL S.A. (FR) | 1992-09-01 | — | — | US | disclosed |