Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL22127330 | 0.98 | IDO1 (0.41) | SIGMAR1IDO1PDPK1SRD5A1CA1 | |
| SCHEMBL9940902 | 0.84 | KMT2A (0.37) | — | |
| SCHEMBL9940942 | 0.84 | KMT2A (0.37) | — | |
| SCHEMBL30804405 | 0.84 | KMT2A (0.37) | — | |
| SCHEMBL9971048 | 0.84 | KMT2A (0.37) | — | |
| SCHEMBL11043930 | 0.79 | CHRM2 (0.41) | SIGMAR1IDO1PDPK1CYP11B2CHRNA7 | |
| SCHEMBL11042908 | 0.79 | CHRM2 (0.41) | SIGMAR1IDO1PDPK1CYP11B2CHRNA7 | |
| SCHEMBL11043928 | 0.79 | CHRM2 (0.41) | SIGMAR1IDO1PDPK1CYP11B2CHRNA7 | |
| SCHEMBL15866390 | 0.77 | SIGMAR1 (0.39) | SIGMAR1IDO1PDPK1SRD5A1CA1 | |
| SCHEMBL11364253 | 0.71 | HRH4 (0.41) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11034663-B2 | Tetrahydronaphtho[1,2-b]furan-2(3H)-one derivatives and preparation and uses thereof | Shanghai Qingdong Biotechnology Co., Ltd (CN) | 2021-06-15 | — | — | US | disclosed |
| US-20200199089-A1 | TETRAHYDRONAPHTHO[1,2-B]FURAN-2(3H)-ONE DERIVATIVES AND PREPARATION AND USES THEREOF | Shanghai Qingdong Biotechnology Co., Ltd. (CN) | 2020-06-25 | — | — | US | disclosed |
| US-5292768-A | Compound effective as cerebral insufficiency improver | SUNTORY LIMITED (JP) | 1994-03-08 | — | — | US | disclosed |
| US-5288752-A | Brain disorders | SUNTORY LIMITED (JP) | 1994-02-22 | — | — | US | disclosed |
| EP-0322248-B1 | COMPOUNDS EFFECTIVE AGAINST CEREBRAL INSUFFICIENCY | SUNTORY LIMITED (JP) | 1993-08-04 | — | — | EP | disclosed |
| US-5179092-A | Cognition activators | SUNTORY LIMITED (JP) | 1993-01-12 | — | — | US | disclosed |
| US-5057514-A | Compounds effective as cerebral schemia treating agents | SUNTORY LIMITED (JP) | 1991-10-15 | — | — | US | disclosed |
| EP-0322248-A2 | Compounds effective against cerebral insufficiency | SUNTORY LIMITED (JP) | 1989-06-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200199089-A1 | TETRAHYDRONAPHTHO[1,2-B]FURAN-2(3H)-ONE DERIVATIVES AND PREPARATION AND USES THEREOF | NR0B1, FOXM1, CYP1A1 | SIGMAR1 1193/4885IDO1 2292/4885PDPK1 3178/4885 |
| US-11034663-B2 | Tetrahydronaphtho[1,2-b]furan-2(3H)-one derivatives and preparation and uses thereof | NR0B1, FOXM1, CYP1A1 | SIGMAR1 1193/4885IDO1 2292/4885PDPK1 3178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.