Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SSTR4 | P31391 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10265288 | 0.87 | POLB (0.53) | TSHRL3MBTL1POLBALDH1A1CYP2D6 | |
| SCHEMBL20159607 | 0.83 | L3MBTL1 (0.51) | TSHRL3MBTL1POLBALDH1A1CYP2D6 | |
| SCHEMBL13783325 | 0.80 | L3MBTL1 (0.61) | TSHRL3MBTL1ALDH1A1CYP2D6HRH3 | |
| SCHEMBL17625632 | 0.80 | L3MBTL1 (0.57) | TSHRL3MBTL1POLBALDH1A1CYP2D6 | |
| SCHEMBL9344169 | 0.80 | TSHR (0.39) | TSHRL3MBTL1POLBALDH1A1CYP2D6 | |
| SCHEMBL13783322 | 0.79 | MAPK1 (0.53) | TSHRL3MBTL1POLBALDH1A1GAA | |
| SCHEMBL19640010 | 0.79 | POLB (0.46) | TSHRL3MBTL1POLBALDH1A1CYP2D6 | |
| SCHEMBL19522186 | 0.79 | POLB (0.46) | TSHRL3MBTL1POLBALDH1A1CYP2D6 | |
| SCHEMBL19640008 | 0.79 | POLB (0.46) | TSHRL3MBTL1POLBALDH1A1CYP2D6 | |
| SCHEMBL13783326 | 0.78 | L3MBTL1 (0.64) | TSHRL3MBTL1ALDH1A1CYP2D6HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5280031-A | Cyclic azaaliphatic compounds with a nitroxy function, processes for the preparation thereof and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM GMBH (DE) | 1994-01-18 | — | — | US | disclosed |
| US-5030641-A | Treatment of angina pectoris, hypotensive agents | BOEHRINGER MANNHEIM GMBH (DE) | 1991-07-09 | — | — | US | disclosed |