Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | USP7 | Q93009 | 1/20 | 0.37 |
| ▸ | USP47 | Q96K76 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9344119 | 0.94 | MAPK1 (0.40) | L3MBTL1LMNAPOLBALDH1A1EPHX2 | |
| SCHEMBL9344988 | 0.84 | EPHX2 (0.40) | TSHRL3MBTL1LMNAPOLBALDH1A1 | |
| SCHEMBL9344103 | 0.82 | ALDH1A1 (0.42) | TSHRALDH1A1EPHX2GAARAB9A | |
| SCHEMBL10265288 | 0.82 | POLB (0.53) | TSHRL3MBTL1LMNAPOLBALDH1A1 | |
| SCHEMBL9348981 | 0.80 | LMNA (0.43) | LMNAALDH1A1KMT2A | |
| SCHEMBL9345071 | 0.80 | POLB (0.65) | TSHRL3MBTL1POLBEPHX2 | |
| SCHEMBL9344112 | 0.80 | TSHR (0.42) | TSHRL3MBTL1POLBALDH1A1EPHX2 | |
| SCHEMBL9329950 | 0.80 | EPHX1 (0.43) | LMNAPKMMEN1KMT2A | |
| SCHEMBL9332607 | 0.80 | KDM4E (0.43) | LMNAPOLBALDH1A1EPHX2PKM | |
| SCHEMBL9333191 | 0.80 | EPHX1 (0.43) | LMNAPKMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5280031-A | Cyclic azaaliphatic compounds with a nitroxy function, processes for the preparation thereof and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM GMBH (DE) | 1994-01-18 | — | — | US | disclosed |
| US-5030641-A | Treatment of angina pectoris, hypotensive agents | BOEHRINGER MANNHEIM GMBH (DE) | 1991-07-09 | — | — | US | disclosed |