Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9344148 | 0.86 | FKBP1A (0.35) | SMN1; SMN2TSHRPOLBKMT2AFKBP1A | |
| SCHEMBL9799548 | 0.81 | PRCP (0.41) | SMN1; SMN2TSHRPOLBKMT2A | |
| SCHEMBL9332542 | 0.81 | BCHE (0.37) | SMN1; SMN2POLBKMT2ACYP3A4EPHX2 | |
| SCHEMBL9348885 | 0.77 | TSHR (0.50) | TSHRKMT2ACYP3A4ALDH1A1 | |
| SCHEMBL9345022 | 0.76 | POLB (0.38) | SMN1; SMN2POLBKMT2AFKBP1ACYP3A4 | |
| SCHEMBL10304470 | 0.76 | NAAA (0.59) | FKBP1ANPSR1EPHX2 | |
| SCHEMBL9348800 | 0.75 | CYP3A4 (0.42) | SMN1; SMN2TSHRPOLBKMT2AFKBP1A | |
| SCHEMBL12733433 | 0.75 | NPSR1 (0.47) | TSHRPOLBFKBP1ANPSR1CYP3A4 | |
| SCHEMBL13396913 | 0.75 | KMT2A (0.47) | SMN1; SMN2TSHRPOLBKMT2AFKBP1A | |
| SCHEMBL16083499 | 0.74 | CYP3A4 (0.41) | TSHRPOLBKMT2AFKBP1ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5280031-A | Cyclic azaaliphatic compounds with a nitroxy function, processes for the preparation thereof and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM GMBH (DE) | 1994-01-18 | — | — | US | disclosed |
| US-5030641-A | Treatment of angina pectoris, hypotensive agents | BOEHRINGER MANNHEIM GMBH (DE) | 1991-07-09 | — | — | US | disclosed |