Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.56 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.53 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.53 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.53 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.52 |
| ▸ | CETP | P11597 | 2/20 | 0.47 |
| ▸ | AMPD2 | Q01433 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26616861 | 0.86 | EPHX1 (0.55) | EPHX1PLA2G10PLA2G2APLA2G5TRPM8 | |
| SCHEMBL933480 | 0.82 | TAAR1 (0.49) | GRIN2BTAAR1 | |
| SCHEMBL934347 | 0.82 | TAAR1 (0.66) | TAAR1 | |
| SCHEMBL934005 | 0.82 | EPHX1 (0.60) | EPHX1PLA2G10PLA2G2APLA2G5GRIN2B | |
| SCHEMBL14478257 | 0.82 | TAAR1 (0.65) | EPHX1CETPCHRM2CHRM1CHRM3 | |
| SCHEMBL934426 | 0.82 | EPHX1 (0.49) | EPHX1PLA2G10PLA2G2APLA2G5TRPM8 | |
| SCHEMBL1416997 | 0.81 | CETP (0.56) | CETPCHRM2CHRM1CHRM3CNR1 | |
| SCHEMBL2662597 | 0.81 | CETP (0.51) | CETPCHRM2CHRM1CHRM3CNR1 | |
| SCHEMBL793094 | 0.79 | SLC7A5 (0.57) | EPHX1TRPM8 | |
| SCHEMBL793095 | 0.79 | SLC7A5 (0.57) | EPHX1TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1780821-A | Heterocyclic kinase inhibitors. | ABBOTT LAB (US) | 2006-05-31 | — | — | CN | claimed |
| EP-2945929-A1 | ACYLGUANIDINES FOR TREATING OSTEOARTHRITIS | Merck Patent GmbH (DE) | 2015-11-25 | — | — | EP | disclosed |
| WO-2014111113-A1 | ACYLGUANIDINES FOR TREATING OSTEOARTHRITIS | MERCK PATENT GMBH (DE) | 2014-07-24 | — | — | WO | disclosed |
| WO-2011006935-A2 | TETRAZOLE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-01-20 | — | — | WO | disclosed |
| CN-1780821-A | Heterocyclic kinase inhibitors. | ABBOTT LAB (US) | 2006-05-31 | — | — | CN | disclosed |