Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.60 |
| ▸ | ACACB | O00763 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | FPR2 | P25090 | 2/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24915125 | 0.86 | ACACB (0.54) | EPHX1ACACBPTPN1EPHX2PPARG | |
| SCHEMBL15569323 | 0.86 | ACACB (0.54) | EPHX1ACACBPTPN1EPHX2PPARG | |
| SCHEMBL934550 | 0.82 | EPHX1 (0.56) | EPHX1GRIN2BPLA2G10PLA2G2APLA2G5 | |
| SCHEMBL933616 | 0.82 | PPARG (0.59) | EPHX1ACACBPTPN1EPHX2PPARG | |
| SCHEMBL14032635 | 0.82 | PPARG (0.60) | PTPN1PPARGPPARA | |
| SCHEMBL933857 | 0.80 | LDHA (0.61) | EPHX1ACACBPPARGPPARA | |
| SCHEMBL934355 | 0.80 | EPHX1 (0.52) | EPHX1ACACBPTPN1EPHX2PPARG | |
| SCHEMBL934143 | 0.79 | EPHX1 (0.45) | EPHX1EPHX2PPARGPPARA | |
| SCHEMBL15881521 | 0.79 | CTSD (0.44) | EPHX1EPHX2PLA2G10PLA2G2APLA2G5 | |
| SCHEMBL1416925 | 0.78 | ACACB (0.52) | EPHX1ACACBPTPN1EPHX2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1780821-A | Heterocyclic kinase inhibitors. | ABBOTT LAB (US) | 2006-05-31 | — | — | CN | claimed |
| WO-2011037833-A2 | NOVEL N-BENZYLAMIDE SUBSTITUTED DERIVATIVES OF 2-(ACYLAMIDO)ACETIC ACID AND 2-(ACYLAMIDO)PROPIONIC ACIDS: POTENT NEUROLOGICAL AGENTS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2011-03-31 | — | — | WO | disclosed |
| WO-2011006935-A2 | TETRAZOLE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-01-20 | — | — | WO | disclosed |
| CN-1780821-A | Heterocyclic kinase inhibitors. | ABBOTT LAB (US) | 2006-05-31 | — | — | CN | disclosed |