Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 8/20 | 0.49 |
| ▸ | HTR6 | P50406 | 5/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MPI | P34949 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9344872 | 0.88 | TSHR (0.53) | TSHRALOX15HTR7HTR6HTR1A | |
| SCHEMBL9349813 | 0.86 | TSHR (0.48) | TSHRALOX15HTR7HTR6HTR1A | |
| SCHEMBL9397232 | 0.85 | TSHR (0.53) | TSHRALOX15HTR7HTR6HTR1A | |
| SCHEMBL9398483 | 0.85 | KDM4E (0.50) | TSHRALOX15HTR7HTR6HTR1A | |
| SCHEMBL9349857 | 0.85 | TSHR (0.50) | TSHRALOX15HTR7HTR6HTR1A | |
| SCHEMBL9344898 | 0.85 | TSHR (0.46) | TSHRALOX15HTR7HTR6HTR1A | |
| SCHEMBL9346885 | 0.85 | ALOX15 (0.46) | TSHRALOX15HTR7HTR6HTR1A | |
| SCHEMBL9200741 | 0.84 | KDM4E (0.52) | KDM4EALDH1A1HPGDHSD17B10IKBKB | |
| SCHEMBL9349900 | 0.84 | TSHR (0.50) | TSHRALOX15HTR7HTR6HTR1A | |
| Hydrochloric Acid SCHEMBL9346272 | 0.84 | TSHR (0.46) | TSHRALOX15HTR7HTR6HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5326870-A | Asthma; bronchodilator agents; respiratory system disorders | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1994-07-05 | — | — | US | disclosed |
| EP-0525203-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVE OR PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1993-02-03 | — | — | EP | disclosed |