Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 5/20 | 0.56 |
| ▸ | HTR2C | P28335 | 5/20 | 0.54 |
| ▸ | HTR2B | P41595 | 4/20 | 0.54 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6620989 | 0.94 | GRIN2B (0.62) | GRIN2BHTR2CHTR2BOPRL1OPRM1 | |
| SCHEMBL10153496 | 0.89 | HTR2C (0.49) | GRIN2BHTR2CHTR2BOPRL1OPRM1 | |
| SCHEMBL8673995 | 0.85 | GRIN2B (0.68) | GRIN2BOPRL1OPRM1OPRK1HTR2A | |
| SCHEMBL9947176 | 0.85 | GRIN2B (0.68) | GRIN2BOPRL1OPRM1OPRK1HTR2A | |
| SCHEMBL9727205 | 0.85 | GRIN2B (0.68) | GRIN2BOPRL1OPRM1OPRK1HTR2A | |
| SCHEMBL9018525 | 0.84 | GRIN2B (0.66) | GRIN2BOPRL1OPRM1OPRK1HTR2A | |
| SCHEMBL9947164 | 0.84 | GRIN2B (0.66) | GRIN2BOPRL1OPRM1OPRK1HTR2A | |
| SCHEMBL9506641 | 0.84 | GRIN2B (0.66) | GRIN2BOPRL1OPRM1OPRK1HTR2A | |
| SCHEMBL7436031 | 0.84 | GRIN2B (0.66) | GRIN2BOPRL1OPRM1OPRK1HTR2A | |
| Hydrochloric Acid SCHEMBL7938970 | 0.82 | GRIN2B (0.64) | GRIN2BOPRL1OPRM1OPRK1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0343830-B1 | Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes | LILLY CO ELI (US) | 1994-07-13 | — | — | EP | disclosed |
| US-5026707-A | Antiserotonine agents | ELI LILLY AND COMPANY (US) | 1991-06-25 | — | — | US | disclosed |
| EP-0343830-A2 | Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes | ELI LILLY AND COMPANY (US) | 1989-11-29 | — | — | EP | disclosed |