Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 3/20 | 0.43 |
| ▸ | PTGS2 known ✓ | P35354 | 3/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | GSR | P00390 | 2/20 | 0.53 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.47 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.44 |
| ▸ | GRM8 | O00222 | 1/20 | 0.44 |
| ▸ | GRM6 | O15303 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL11276606 | 0.92 | THRB (0.58) | THRBGSRITGB3ITGA2BCPB2 | |
| (R)-Ibuprophen SCHEMBL29696062 | 0.84 | THRB (0.73) | THRBGSRITGB3ITGA2BMMP2 | |
| Dexibuprofen SCHEMBL8733957 | 0.84 | THRB (0.73) | THRBGSRITGB3ITGA2BMMP2 | |
| Ibuprofen SCHEMBL44616 | 0.84 | THRB (0.73) | THRBGSRITGB3ITGA2BMMP2 | |
| (R)-Ibuprophen SCHEMBL8579043 | 0.84 | THRB (0.73) | THRBGSRITGB3ITGA2BMMP2 | |
| Ibuprofen SCHEMBL44617 | 0.84 | THRB (0.73) | THRBGSRITGB3ITGA2BMMP2 | |
| Dexibuprofen SCHEMBL875767 | 0.84 | THRB (0.73) | THRBGSRITGB3ITGA2BMMP2 | |
| Dexibuprofen SCHEMBL379398 | 0.83 | THRB (0.72) | THRBGSRITGB3ITGA2BMMP2 | |
| Ibuprofen SCHEMBL8902943 | 0.83 | THRB (0.72) | THRBGSRITGB3ITGA2BMMP2 | |
| Ibuprofen SCHEMBL8902948 | 0.83 | THRB (0.72) | THRBGSRITGB3ITGA2BMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0253083-B1 | Topical vaginal use of lysine p-isobutylphenylpropionate in antiinflammatory treatment | LISAPHARMA SPA (IT) | 1994-08-31 | — | — | EP | claimed |
| US-4755533-A | Topical vaginal use of lysine p-isobutylphenylpropionate in anti-inflammatory treatment | LABORATORIO ITALIANO BIOCHIMICO FARMACEUTICO LISAPHARMA SPA (IT) | 1988-07-05 | — | — | US | claimed |
| EP-0253083-A2 | Topical vaginal use of lysine p-isobutylphenylpropionate in antiinflammatory treatment | LABORATORIO ITALIANO BIOCHIMICO FARMACEUTICO LISAPHARMA S.P.A. (IT) | 1988-01-20 | — | — | EP | claimed |
| EP-0253083-B1 | Topical vaginal use of lysine p-isobutylphenylpropionate in antiinflammatory treatment | LISAPHARMA SPA (IT) | 1994-08-31 | — | — | EP | disclosed |
| EP-0253083-B1 | Topical vaginal use of lysine p-isobutylphenylpropionate in antiinflammatory treatment | LISAPHARMA SPA (IT) | 1994-08-31 | — | — | EP | disclosed |
| US-4755533-A | Topical vaginal use of lysine p-isobutylphenylpropionate in anti-inflammatory treatment | LABORATORIO ITALIANO BIOCHIMICO FARMACEUTICO LISAPHARMA SPA (IT) | 1988-07-05 | — | — | US | disclosed |
| US-4755533-A | Topical vaginal use of lysine p-isobutylphenylpropionate in anti-inflammatory treatment | LABORATORIO ITALIANO BIOCHIMICO FARMACEUTICO LISAPHARMA SPA (IT) | 1988-07-05 | — | — | US | disclosed |
| US-4755533-A | Topical vaginal use of lysine p-isobutylphenylpropionate in anti-inflammatory treatment | LABORATORIO ITALIANO BIOCHIMICO FARMACEUTICO LISAPHARMA SPA (IT) | 1988-07-05 | — | — | US | disclosed |
| EP-0253083-A2 | Topical vaginal use of lysine p-isobutylphenylpropionate in antiinflammatory treatment | LABORATORIO ITALIANO BIOCHIMICO FARMACEUTICO LISAPHARMA S.P.A. (IT) | 1988-01-20 | — | — | EP | disclosed |
| EP-0253083-A2 | Topical vaginal use of lysine p-isobutylphenylpropionate in antiinflammatory treatment | LABORATORIO ITALIANO BIOCHIMICO FARMACEUTICO LISAPHARMA S.P.A. (IT) | 1988-01-20 | — | — | EP | disclosed |
| EP-0253083-A2 | Topical vaginal use of lysine p-isobutylphenylpropionate in antiinflammatory treatment | LABORATORIO ITALIANO BIOCHIMICO FARMACEUTICO LISAPHARMA S.P.A. (IT) | 1988-01-20 | — | — | EP | disclosed |