Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dexibuprofen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 5/20 | 0.64 |
| ▸ | PTGS2 known ✓ | P35354 | 5/20 | 0.64 |
| ▸ | THRB | P10828 | 1/20 | 0.72 |
| ▸ | CXCR1 | P25024 | 3/20 | 0.64 |
| ▸ | CXCR2 | P25025 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.64 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.64 |
| ▸ | ALB | P02768 | 1/20 | 0.64 |
| ▸ | ESR1 | P03372 | 1/20 | 0.64 |
| ▸ | RARB | P10826 | 1/20 | 0.64 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.64 |
| ▸ | HTR2A | P28223 | 1/20 | 0.64 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.64 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.64 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ibuprofen SCHEMBL8902943 | 1.00 | THRB (0.72) | THRBPTGS1PTGS2CXCR1CXCR2 | |
| Ibuprofen SCHEMBL8902948 | 1.00 | THRB (0.72) | THRBPTGS1PTGS2CXCR1CXCR2 | |
| (R)-Ibuprophen SCHEMBL29696062 | 0.99 | THRB (0.73) | THRBPTGS1PTGS2CXCR1CXCR2 | |
| Ibuprofen SCHEMBL44616 | 0.99 | THRB (0.73) | THRBPTGS1PTGS2CXCR1CXCR2 | |
| Dexibuprofen SCHEMBL875767 | 0.99 | THRB (0.73) | THRBPTGS1PTGS2CXCR1CXCR2 | |
| Dexibuprofen SCHEMBL8733957 | 0.99 | THRB (0.73) | THRBPTGS1PTGS2CXCR1CXCR2 | |
| Ibuprofen SCHEMBL44617 | 0.99 | THRB (0.73) | THRBPTGS1PTGS2CXCR1CXCR2 | |
| (R)-Ibuprophen SCHEMBL8579043 | 0.99 | THRB (0.73) | THRBPTGS1PTGS2CXCR1CXCR2 | |
| Lysine SCHEMBL11276603 | 0.91 | THRB (0.71) | THRBPTGS1PTGS2CXCR1CXCR2 | |
| Ibuprofen SCHEMBL20775003 | 0.85 | PTGS1 (0.64) | THRBPTGS1PTGS2CXCR1CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 188 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4000602-A1 | NOVEL ZN(II)-NSAID-COMPLEX COMPOSITION | concrete flowers GmbH (AT) | 2022-05-25 | — | — | EP | claimed |
| CN-107854469-A | Topical ophthalmic or the husky star medicine of ear or nose use or external preparation for skin and combinations thereof | 刘力 | 2018-03-30 | — | — | CN | claimed |
| US-20120183600-A1 | NOVEL COMPOSITION FOR TREATING METABOLIC SYNDROME AND OTHER CONDITIONS | CHEN CHIEN-HUNG (US) | 2012-07-19 | — | — | US | claimed |
| CN-100377745-C | Stabilized medicine preparation form with by porous kietyoite covering flavour | XINGLI NAIMI BIOTECHNOLOGY CO (CN) | 2008-04-02 | — | — | CN | claimed |
| CN-1688292-A | Taste masked dosage form and method of making same | RANBAXY LAB LTD (IN) | 2005-10-26 | — | — | CN | claimed |
| CN-1423555-A | Taste-masking coating compositions | BRISTOL MYERS SQUIBB CO (US) | 2003-06-11 | — | — | CN | claimed |
| EP-0505180-B1 | High-content ibuprofen lysinate pharmaceutical formulation | MERCK & CO INC (US) | 1996-10-09 | — | — | EP | claimed |
| EP-0459695-B1 | Taste masking and sustained release coatings for pharmaceuticals | MCNEIL PPC INC (US) | 1995-03-15 | — | — | EP | claimed |
| US-5075114-A | Chewable tablet of compressed granules of medicament coated wi th blend of cellulose acetate, cellulose acetate butyrate, hyd roxypropyl cellulose | MCNEIL-PPC, INC. (US) | 1991-12-24 | — | — | US | claimed |
| EP-0459695-A1 | Taste masking and sustained release coatings for pharmaceuticals | McNEIL-PPC, INC. (US) | 1991-12-04 | — | — | EP | claimed |
| EP-3782649-B1 | BIODEGRADABLE POLYETHYLENE GLYCOL BASED WATER-INSOLUBLE HYDROGELS | ASCENDIS PHARMA AS (DK) | 2025-05-14 | — | — | EP | disclosed |
| US-20230381323-A1 | RELEASABLE CONJUGATES | FISH & RICHARDSON PC | 2023-11-30 | — | — | US | disclosed |
| US-11786599-B2 | Releasable conjugates | QUIAPEG PHARMACEUTICALS AB (SE) | 2023-10-17 | — | — | US | disclosed |
| CN-110505874-B | Molecules having pesticidal utility, and intermediates, compositions and methods related thereto | 科迪华农业科技有限责任公司 | 2023-09-26 | — | — | CN | disclosed |
| US-20230123784-A1 | Biodegradable Polyethylene Glycol Based Water-Insoluble Hydrogels | ASCENDIS PHARMA A/S (DK) | 2023-04-20 | — | — | US | disclosed |
| EP-0459695-B1 | Taste masking and sustained release coatings for pharmaceuticals | MCNEIL PPC INC (US) | 1995-03-15 | — | — | EP | disclosed |
| US-5233793-A | Knife sharpening cutting board | IDAHO WOODWORKS, INC. | 1993-08-10 | — | — | US | disclosed |
| US-5075114-A | Chewable tablet of compressed granules of medicament coated wi th blend of cellulose acetate, cellulose acetate butyrate, hyd roxypropyl cellulose | MCNEIL-PPC, INC. (US) | 1991-12-24 | — | — | US | disclosed |
| EP-0459695-A1 | Taste masking and sustained release coatings for pharmaceuticals | McNEIL-PPC, INC. (US) | 1991-12-04 | — | — | EP | disclosed |
| EP-0130166-A1 | A recombinant plasmid, a transformant microorganism, a polydeoxy-ribonucleotide segment, a process for producing a biologically active protein, and the protein thus produced | KabiGen AB (SE) | 1985-01-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230123784-A1 | Biodegradable Polyethylene Glycol Based Water-Insoluble Hydrogels | PLG, PHYKPL, PLOD3 | PTGS1 31/4885PTGS2 114/4885THRB 2856/4885 |
| US-20230381323-A1 | RELEASABLE CONJUGATES | GUSB, ABCB11, UGT2B7 | PTGS1 2524/4885PTGS2 2908/4885THRB 1120/4885 |
| US-11786599-B2 | Releasable conjugates | GUSB, ABCB11, UGT2B7 | PTGS1 2524/4885PTGS2 2908/4885THRB 1120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.