Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.72 |
| ▸ | NPC1 | O15118 | 3/20 | 0.64 |
| ▸ | RAB9A | P51151 | 3/20 | 0.64 |
| ▸ | CDK4 | P11802 | 1/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | IAPP | P10997 | 3/20 | 0.51 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.51 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4064581 | 0.85 | KMT2A (1.00) | KMT2ANPC1RAB9ACDK4HTT | |
| SCHEMBL13869716 | 0.84 | KMT2A (0.84) | KMT2ANPC1RAB9ACDK4BCHE | |
| SCHEMBL12655458 | 0.78 | TRPM8 (0.60) | KMT2ANPC1RAB9AAPPIGF1R | |
| SCHEMBL7442885 | 0.77 | KMT2A (0.77) | KMT2ANPC1RAB9ABCHEACHE | |
| SCHEMBL9346628 | 0.77 | IAPP (0.62) | KMT2ANPC1RAB9AAPPIGF1R | |
| SCHEMBL4072151 | 0.76 | NPC1 (0.85) | KMT2ANPC1RAB9ACDK4BCHE | |
| SCHEMBL7544044 | 0.76 | IGF1R (0.57) | KMT2AAPPIGF1RALOX15BCHE | |
| SCHEMBL1690816 | 0.75 | NPC1 (0.82) | KMT2ANPC1RAB9ACDK4BCHE | |
| SCHEMBL12290151 | 0.75 | NPC1 (0.82) | KMT2ANPC1RAB9ACDK4MEN1 | |
| SCHEMBL7282371 | 0.75 | NPC1 (0.89) | KMT2ANPC1RAB9ACDK4BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0333522-B1 | Catechol derivatives and pharmaceutical preparations containing same | MITSUI TOATSU CHEMICALS (JP) | 1994-08-17 | — | — | EP | disclosed |
| US-5232923-A | Stimulates production of nerve growth factor; administering for treatment of regressive disorders of the central nervous system | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1993-08-03 | — | — | US | disclosed |
| EP-0333522-A2 | Catechol derivatives and pharmaceutical preparations containing same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1989-09-20 | — | — | EP | disclosed |