SCHEMBL9347642

SCHEMBL9347642

O=[C]C(c1ccc(Cl)cc1)S(=O)(=O)O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABBR2 O75899 4/20 0.43
GABBR1 Q9UBS5 4/20 0.43
BRD4 O60885 1/20 0.37
HDAC4 P56524 1/20 0.37
HDAC7 Q8WUI4 1/20 0.37
HDAC5 Q9UQL6 1/20 0.37
FFAR2 O15552 1/20 0.37
MAPK1 P28482 3/20 0.37
CYP3A4 P08684 2/20 0.37
ALDH1A1 P00352 1/20 0.37
TSHR P16473 3/20 0.35
HIF1A Q16665 2/20 0.35
TDP1 Q9NUW8 2/20 0.35
CA1 P00915 3/20 0.35
CA2 P00918 3/20 0.35
MMP1 P03956 1/20 0.35
MMP2 P08253 1/20 0.35
MMP9 P14780 1/20 0.35
MMP8 P22894 1/20 0.35
MMP13 P45452 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10403045 0.84 GABBR2 (0.43) GABBR2GABBR1BRD4HDAC4HDAC7
SCHEMBL9329549 0.82 SRC (0.50) CYP3A4ALDH1A1TSHRHIF1ATDP1
SCHEMBL10774890 0.80 HDAC3 (0.37) GABBR2GABBR1HDAC4HDAC7HDAC5
SCHEMBL9347446 0.80 TSHR (0.43) CYP3A4ALDH1A1TSHRTDP1CA1
SCHEMBL7766303 0.80 CHRNA7 (0.39) MAPK1ALDH1A1TDP1CA1CA2
SCHEMBL11305578 0.79 ALDH1A1 (0.37) MAPK1CYP3A4ALDH1A1TDP1LMNA
SCHEMBL6276092 0.79 SRC (0.50) MAPK1ALDH1A1TSHRTDP1LMNA
SCHEMBL10404138 0.76 CA1 (0.44) MAPK1ALDH1A1TSHRTDP1CA1
SCHEMBL9347491 0.74 CA2 (0.45) MAPK1CYP3A4ALDH1A1TSHRTDP1
SCHEMBL9350834 0.73 KDM4E (0.40) MAPK1CYP3A4ALDH1A1TSHRHIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5300497-A Broad spectrum antibiotics and bactericides; stable to beta-lactamase; effective against antibiotic-resistant bacteria TOYAMA CHEMICAL CO., LTD. (JP) 1994-04-05 US disclosed
US-5185330-A Penicillins/ad/ TOYAMA CHEMICAL CO., LTD. (JP) 1993-02-09 US disclosed
US-4914206-A ANTIBIOTICS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1990-04-03 US disclosed
EP-0226896-A2 Lankacidin derivatives and production thereof Takeda Chemical Industries, Ltd. (JP) 1987-07-01 EP disclosed
US-4281116-A ANTIBIOTICS ELI LILLY AND COMPANY (US) 1981-07-28 US disclosed
US-4260745-A 3-Halo cephalosporins ELI LILLY AND COMPANY (US) 1981-04-07 US disclosed
US-4252950-A ANTIBIOTICS, BACTERICIDES, FUNGICIDES ELI LILLY AND COMPANY (US) 1981-02-24 US disclosed
US-4208515-A 3-Halo cephalosporins ELI LILLY AND COMPANY (US) 1980-06-17 US disclosed
US-4064343-A ANTIBIOTICS ELI LILLY AND COMPANY (US) 1977-12-20 US disclosed
US-3992377-A 3-Thio-substituted cephalosporin antibiotics ELI LILLY AND COMPANY (US) 1976-11-16 US disclosed
US-3962227-A ANTIBIOTICS ELI LILLY AND COMPANY (US) 1976-06-08 US disclosed