SCHEMBL9348115

SCHEMBL9348115

O=C(CC(=O)C(F)(F)C(F)(F)C(F)(F)F)c1ccc(Cl)c(Cl)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMO O15229 3/20 0.44
TSHR P16473 1/20 0.43
HTT P42858 2/20 0.42
HPGD P15428 2/20 0.42
POLB P06746 1/20 0.42
PLOD2 O00469 1/20 0.41
HSD11B1 P28845 1/20 0.41
HDAC3 O15379 2/20 0.41
HDAC4 P56524 2/20 0.41
HDAC1 Q13547 2/20 0.41
HDAC7 Q8WUI4 2/20 0.41
HDAC2 Q92769 2/20 0.41
HDAC10 Q969S8 2/20 0.41
HDAC11 Q96DB2 2/20 0.41
HDAC8 Q9BY41 2/20 0.41
HDAC6 Q9UBN7 2/20 0.41
HDAC9 Q9UKV0 2/20 0.41
HDAC5 Q9UQL6 2/20 0.41
MEN1 O00255 2/20 0.41
NPC1 O15118 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10876400 0.87 PLOD2 (0.39) KMOHTTPLOD2MEN1NPC1
SCHEMBL1349410 0.84 PLOD2 (0.59) KMOTSHRHTTHPGDPOLB
SCHEMBL1999729 0.84 PLOD2 (0.56) HTTHPGDPOLBPLOD2HDAC1
SCHEMBL6344726 0.83 ERCC5 (0.50) POLBPLOD2HDAC1HDAC7HDAC8
SCHEMBL10875643 0.83 VCAM1 (0.54) HPGDPOLBMEN1MAPTKMT2A
SCHEMBL8913602 0.80 RAB9A (0.39) PLOD2MEN1RAB9AKMT2A
SCHEMBL9015106 0.78 TSHR (0.61) KMOTSHRHTTHPGDPOLB
SCHEMBL25403646 0.78 PLOD2 (0.41) KMOPLOD2HDAC1MEN1RAB9A
SCHEMBL1095075 0.78 PTPN1 (0.51) HPGDPLOD2HDAC3HDAC4HDAC1
SCHEMBL10875483 0.76 PTPN1 (0.58) PLOD2HSD11B1HDAC1HDAC8MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0317275-B1 Control of ectoparasites BRITISH TECH GROUP USA (US) 1994-08-03 EP claimed