Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9348224 | 0.91 | HSD17B10 (0.41) | CYP1A2CYP2C19MAPTMEN1KMT2A | |
| SCHEMBL9348283 | 0.91 | MAPT (0.46) | CYP1A2CYP2C19MAPTMEN1KMT2A | |
| SCHEMBL10377542 | 0.89 | MAPT (0.44) | CYP1A2CYP2C19MAPTHPGDKDM4E | |
| SCHEMBL10378878 | 0.89 | KAT2B (0.42) | MAPTMEN1KMT2AKDM4EPTGDR2 | |
| SCHEMBL9349392 | 0.88 | FEN1 (0.49) | CYP1A2CYP2C19MAPTHPGDKDM4E | |
| SCHEMBL10377279 | 0.87 | SMN1; SMN2 (0.44) | CYP1A2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL9799559 | 0.80 | CYP1A2 (0.44) | CYP1A2CYP2C19MAPTMEN1KMT2A | |
| SCHEMBL10427752 | 0.80 | KMT2A (0.50) | CYP1A2CYP2C19MAPTMEN1KMT2A | |
| SCHEMBL9348174 | 0.80 | MAPT (0.44) | CYP1A2CYP2C19MAPTHPGDKDM4E | |
| SCHEMBL10379180 | 0.79 | KAT2B (0.42) | MAPTMEN1KMT2AKDM4EPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5350755-A | Treatment of psoriasis or eczema with naphthyridine derivative | SCHERING CORPORATION (US) | 1994-09-27 | — | — | US | disclosed |
| EP-0144996-B1 | SUBSTITUTED SPIRO PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THE PREPARATION OF SUCH COMPOUNDS AND COMPOSITIONS | SCHERING CORPORATION (US) | 1990-02-28 | — | — | EP | disclosed |
| US-4652564-A | Substituted spiro pyridine derivatives as anti-allergy and antiinflammatory agents | SCHERING CORPORATION (US) | 1987-03-24 | — | — | US | disclosed |
| EP-0144996-A2 | Substituted spiro pyridine derivatives, pharmaceutical compositions containing them and processes for the preparation of such compounds and compositions | SCHERING CORPORATION (US) | 1985-06-19 | — | — | EP | disclosed |