Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | DRD5 | P21918 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 6/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10377267 | 0.88 | KAT2B (0.42) | MAPTPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10377449 | 0.88 | PDE4A (0.51) | CYP1A2CYP2C19MAPTHPGDPDE4A | |
| SCHEMBL9799463 | 0.88 | KAT2B (0.45) | MEN1KMT2AMAPTPDE4APDE4B | |
| SCHEMBL9348283 | 0.81 | MAPT (0.46) | CYP1A2CYP2C19MEN1KMT2AMAPT | |
| SCHEMBL9348307 | 0.80 | CYP1A2 (0.46) | CYP1A2CYP2C19MEN1KMT2AMAPT | |
| SCHEMBL8803476 | 0.80 | PDE4A (0.55) | CYP1A2CYP2C19MAPTHPGDDRD1 | |
| SCHEMBL10427752 | 0.78 | KMT2A (0.50) | CYP1A2CYP2C19MEN1KMT2AMAPT | |
| SCHEMBL9267553 | 0.78 | MAPT (0.47) | CYP1A2CYP2C19MEN1KMT2AMAPT | |
| SCHEMBL7272901 | 0.75 | PDE4A (0.48) | CYP1A2CYP2C19MEN1KMT2AMAPT | |
| SCHEMBL9215901 | 0.74 | MAPT (0.44) | CYP1A2CYP2C19MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4996212-A | Antiinflammatory and anti-hyperproliferative compounds | SCHERING CORPORATION (US) | 1991-02-26 | — | — | US | disclosed |
| US-4859669-A | Antiinflammatory and anti-hyperproliferative naphthyridin-4-ones | SCHERING CORPORATION (US) | 1989-08-22 | — | — | US | disclosed |