Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
| ▸ | TUBB | P07437 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9349868 | 0.81 | CRHR1 (0.35) | ALDH1A1CYP3A4CYP1A2USP2MAPK1 | |
| SCHEMBL9348362 | 0.80 | CYP3A4 (0.33) | ALDH1A1CYP3A4CYP1A2USP2MAPK1 | |
| SCHEMBL9348450 | 0.80 | ALDH1A1 (0.34) | ALDH1A1CYP3A4MEN1MAPTKMT2A | |
| SCHEMBL9348570 | 0.77 | CYP3A4 (0.37) | CYP3A4MAPTCYP1A2CA9TUBB4A | |
| SCHEMBL4002789 | 0.76 | ALDH1A1 (0.46) | ALDH1A1CYP3A4CYP1A2USP2MAPK1 | |
| SCHEMBL1911818 | 0.75 | ALDH1A1 (0.46) | ALDH1A1CYP3A4MEN1MAPTTHRB | |
| SCHEMBL9352152 | 0.74 | MAPT (0.41) | ALDH1A1CYP3A4MEN1MAPTKMT2A | |
| SCHEMBL8708885 | 0.72 | CYP1A2 (0.45) | ALDH1A1CYP3A4MEN1MAPTTHRB | |
| SCHEMBL7952922 | 0.72 | ALDH1A1 (0.46) | ALDH1A1CYP3A4CYP1A2USP2MAPK1 | |
| SCHEMBL9444302 | 0.71 | ALDH1A1 (0.42) | ALDH1A1CYP3A4MEN1MAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992016509-A1 | MULTISUBSTITUTED 1-HYDROXY-9-ACRIDONES WITH ANTICANCER ACTIVITY | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-10-01 | — | — | WO | claimed |
| US-5296602-A | Condensing substituted ortho-halo- or ortho-aminobenzoic acid with meta-halo- or meta-aminoanisole, cyclizing, N-alkylating, de-O-methylating | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1994-03-22 | — | — | US | disclosed |
| WO-1992016509-A1 | MULTISUBSTITUTED 1-HYDROXY-9-ACRIDONES WITH ANTICANCER ACTIVITY | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-10-01 | — | — | WO | disclosed |