Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NEK2 | P51955 | 4/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | CDC25B | P30305 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL700669 | 0.84 | MAPT (0.66) | MAPTTDP1ALDH1A1KDM4EPOLB | |
| SCHEMBL855207 | 0.81 | CTSV (0.54) | MAPTTDP1ALDH1A1KDM4EPOLB | |
| SCHEMBL9348401 | 0.78 | G6PD (0.47) | TDP1ALDH1A1CLCN2KDM4EEGFR | |
| SCHEMBL29091618 | 0.77 | MAPT (0.53) | MAPTTDP1ALDH1A1KDM4ENEK2 | |
| SCHEMBL14907060 | 0.76 | HSD17B10 (0.47) | MAPTTDP1ALDH1A1KDM4ENEK2 | |
| SCHEMBL27143289 | 0.75 | TDP1 (0.49) | MAPTTDP1ALDH1A1KDM4EPOLB | |
| SCHEMBL5925513 | 0.75 | ALDH1A1 (0.68) | MAPTTDP1ALDH1A1CLCN2KDM4E | |
| SCHEMBL11556852 | 0.75 | MAPT (0.50) | MAPTTDP1ALDH1A1KDM4ENEK2 | |
| SCHEMBL23121012 | 0.74 | MAPT (0.53) | MAPTTDP1ALDH1A1KDM4EPTPN1 | |
| SCHEMBL29996551 | 0.74 | MAPT (0.53) | MAPTTDP1ALDH1A1KDM4EPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992016509-A1 | MULTISUBSTITUTED 1-HYDROXY-9-ACRIDONES WITH ANTICANCER ACTIVITY | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-10-01 | — | — | WO | claimed |
| US-5296602-A | Condensing substituted ortho-halo- or ortho-aminobenzoic acid with meta-halo- or meta-aminoanisole, cyclizing, N-alkylating, de-O-methylating | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1994-03-22 | — | — | US | disclosed |
| WO-1992016509-A1 | MULTISUBSTITUTED 1-HYDROXY-9-ACRIDONES WITH ANTICANCER ACTIVITY | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-10-01 | — | — | WO | disclosed |