SCHEMBL9348586

SCHEMBL9348586

O=C1C=C(c2ccc([N+](=O)[O-])cc2)C(=O)N1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
APP P05067 1/20 0.43
METAP1 P53582 1/20 0.42
MAPT P10636 3/20 0.42
LMNA P02545 1/20 0.42
NOTUM Q6P988 1/20 0.41
CA12 O43570 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA9 Q16790 1/20 0.41
CA14 Q9ULX7 1/20 0.41
GAA P10253 1/20 0.41
CAPN9 O14815 1/20 0.40
CASP3 P42574 1/20 0.40
XDH P47989 1/20 0.40
ALDH1A1 P00352 2/20 0.39
ACHE P22303 1/20 0.39
HSD17B10 Q99714 1/20 0.39
POLB P06746 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL448198 0.82 BACE1 (0.32) GSK3BGSK3A
SCHEMBL16668754 0.80 HSD17B3 (0.34)
SCHEMBL2345035 0.80 PTPRC (0.54) METAP1MAPTLMNAPOLBGSK3B
SCHEMBL27146064 0.76 TDP1 (0.53) CYP3A4TDP1MAPTCA12CA1
SCHEMBL2712453 0.75 HAO1 (0.42) TDP1MAPTLMNACA12CA2
SCHEMBL10353320 0.74 CYP3A4 (0.35) CYP3A4LMNACA12CA1CA2
SCHEMBL1087322 0.73 ALDH1A1 (0.42) TDP1MAPTLMNANOTUMGAA
SCHEMBL552048 0.73 MGAM (0.43) TDP1METAP1GAAGSK3B
SCHEMBL3795697 0.73 CYP3A4 (0.40) CYP3A4TDP1APPMAPTCA12
SCHEMBL1232781 0.73 RECQL (0.41) MAPTLMNANOTUMGAAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110724154-A Polysubstituted pyrrolo [3,4-d ] isoxazole derivative and synthetic method thereof 湖北科技学院 2020-01-24 CN claimed
CN-105924445-B Pyrazoles N- p-nitrophenyl maleimide derivatives containing chromone structure and preparation method and application 绍兴文理学院 2017-12-12 CN claimed
CN-105924445-A Pyrazole-type N-p-nitrophenyl maleimide derivative containing chromone structure, and preparation method and application thereof 绍兴文理学院 2016-09-07 CN claimed
CN-101302261-A Polychloroethylene heat stabilizer having dioctyl tin maleate structure and preparation thereof UNIV WENZHOU (CN) 2008-11-12 CN claimed
US-12111313-B2 Chelator-coated field effect transistor and devices and methods using same Autonomous Medical Devices Inc. (US) 2024-10-08 US disclosed
CN-115768805-B Polymer compound and resin composition containing the same 日本化药株式会社 2024-10-01 CN disclosed
US-20210293798-A1 Chelator-Coated Field Effect Transistor and Devices and Methods Using Same Autonomous Medical Devices Inc. (US) 2021-09-23 US disclosed
EP-3837541-A1 CHELATOR-COATED FIELD EFFECT TRANSISTOR AND DEVICES AND METHODS USING SAME Autonomous Medical Devices Incorporated (US) 2021-06-23 EP disclosed
CN-110724154-B Polysubstituted pyrrolo [3,4-d ] isoxazole derivative and synthetic method thereof 湖北科技学院 2020-08-04 CN disclosed
WO-2020037078-A1 CHELATOR-COATED FIELD EFFECT TRANSISTOR AND DEVICES AND METHODS USING SAME Sensor-Kinesis Corporation (US) 2020-02-20 WO disclosed
CN-110724154-A Polysubstituted pyrrolo [3,4-d ] isoxazole derivative and synthetic method thereof 湖北科技学院 2020-01-24 CN disclosed
CN-109988178-A The p-nitrophenyl substituted maleimide amine of N- containing pyrrazole structure α-terpinene cycloaddition derivative and its preparation method and application 绍兴文理学院元培学院 2019-07-09 CN disclosed
US-5087705-A Heating N-substituted maleamic acid monoester in presence of acid catalyst SHIN-DAIKYOWA PETROCHEMICAL CO., LTD. (JP) 1992-02-11 US disclosed
EP-0359464-A2 Heat resistant polyvinyl chloride copolymer and preparation process of the copolymer MITSUI TOATSU CHEMICALS, Inc. (JP) 1990-03-21 EP disclosed
US-4812244-A SULFONATED STYRENE-MALEIMIDE COPOLYMER, SODIUM ACRYLATE-METHACRYLATE COPOLYMER PONY INDUSTRIES, INC. (US) 1989-03-14 US disclosed
US-4797450-A PHENYLMALEIMIDES WITH STYRENE FOLLOWED BY SULFONATION ARCO CHEMICAL COMPANY (US) 1989-01-10 US disclosed
EP-0143508-A2 Additive for water-base drilling fluid and process ATLANTIC RICHFIELD COMPANY (US) 1985-06-05 EP disclosed
US-4302484-A Polymers crosslinkable by electron beams BAYER AKTIENGESELLSCHAFT (DE) 1981-11-24 US disclosed
EP-0001997-B1 ELECTRON BEAM-CURABLE PHOTORESIST LACQUERS BAYER AG (DE) 1981-02-11 EP disclosed
EP-0001997-A1 Electron beam-curable photoresist lacquers BAYER AG (DE) 1979-05-30 EP disclosed