Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 10/20 | 0.38 |
| ▸ | DRD3 | P35462 | 10/20 | 0.38 |
| ▸ | DRD2 | P14416 | 9/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9344976 | 0.82 | EPHX1 (0.43) | EPHX1HPGDKMT2AHTR2ADRD3 | |
| SCHEMBL9344169 | 0.80 | TSHR (0.39) | LMNAKMT2AALDH1A1 | |
| SCHEMBL9344119 | 0.77 | MAPK1 (0.40) | LMNAKMT2AHTR2ADRD3DRD2 | |
| SCHEMBL16420763 | 0.77 | HPGD (0.68) | LMNAEPHX1HPGDKMT2AALDH1A1 | |
| SCHEMBL9332607 | 0.76 | KDM4E (0.43) | LMNAEPHX1ALDH1A1SIGMAR1 | |
| SCHEMBL9329950 | 0.76 | EPHX1 (0.43) | LMNAEPHX1KMT2AHTR2ADRD2 | |
| SCHEMBL9333191 | 0.76 | EPHX1 (0.43) | LMNAEPHX1KMT2AHTR2ADRD2 | |
| SCHEMBL16420562 | 0.76 | HPGD (0.71) | LMNAEPHX1HPGDKMT2AALDH1A1 | |
| SCHEMBL9019581 | 0.75 | ALDH1A1 (0.39) | LMNAALDH1A1 | |
| SCHEMBL9346184 | 0.74 | EPHX1 (0.41) | EPHX1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5280031-A | Cyclic azaaliphatic compounds with a nitroxy function, processes for the preparation thereof and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM GMBH (DE) | 1994-01-18 | — | — | US | disclosed |
| US-5030641-A | Treatment of angina pectoris, hypotensive agents | BOEHRINGER MANNHEIM GMBH (DE) | 1991-07-09 | — | — | US | disclosed |