Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7331126 | 0.79 | KDM4E (0.42) | KDM4E | |
| SCHEMBL7435415 | 0.78 | KDM4E (0.40) | KDM4E | |
| SCHEMBL7274884 | 0.76 | DCTPP1 (0.45) | KDM4E | |
| SCHEMBL7283343 | 0.76 | KDM4E (0.43) | AGTR1AGTR2KDM4E | |
| SCHEMBL7277054 | 0.76 | MEN1 (0.44) | KDM4E | |
| SCHEMBL9346871 | 0.75 | KMT2A (0.49) | — | |
| SCHEMBL7274897 | 0.75 | MAPT (0.39) | — | |
| SCHEMBL3175415 | 0.74 | KDM4E (0.36) | KDM4E | |
| SCHEMBL7283332 | 0.74 | ALOX5AP (0.43) | AGTR1AGTR2 | |
| SCHEMBL7445280 | 0.74 | MAT2A (0.38) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5294620-A | Hypotensive agents or compounds for cardiovascular disorders | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-03-15 | — | — | US | disclosed |
| US-5217976-A | Hypotensive agents, congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-08 | — | — | US | disclosed |