Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | PRKACG | P22612 | 1/20 | 0.46 |
| ▸ | PRKACB | P22694 | 1/20 | 0.46 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.46 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | TYMS | P04818 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7331126 | 0.84 | KDM4E (0.42) | KMT2AMEN1L3MBTL1ALDH1A1TP53 | |
| SCHEMBL9347486 | 0.83 | PKM (0.43) | KMT2AMEN1L3MBTL1P2RX4TP53 | |
| SCHEMBL7435415 | 0.82 | KDM4E (0.40) | KMT2AMEN1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7274884 | 0.81 | DCTPP1 (0.45) | KMT2AMEN1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7283343 | 0.81 | KDM4E (0.43) | KMT2AMEN1L3MBTL1POLBALDH1A1 | |
| SCHEMBL3170012 | 0.78 | KDM4E (0.41) | KMT2AMEN1POLBNPSR1SMN1; SMN2 | |
| SCHEMBL3175415 | 0.77 | KDM4E (0.36) | KMT2ALMNA | |
| SCHEMBL9430723 | 0.75 | KDM4E (0.35) | KMT2AMEN1SRCPRKACAPRKACG | |
| SCHEMBL9350435 | 0.75 | AGTR1 (0.38) | — | |
| SCHEMBL7274709 | 0.74 | PPARG (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5373015-A | Treating hypertension and congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-12-13 | — | — | US | disclosed |
| US-5294620-A | Hypotensive agents or compounds for cardiovascular disorders | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-03-15 | — | — | US | disclosed |
| US-5217976-A | Hypotensive agents, congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-08 | — | — | US | disclosed |