Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | PDE4A | P27815 | 2/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.53 |
| ▸ | PDE5A | O76074 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9350633 | 0.90 | KMT2A (0.57) | CNOT7KMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL9350644 | 0.85 | PDE4A (0.57) | KMT2ATSHRMAPK1PDE4APDE4B | |
| SCHEMBL556890 | 0.83 | PDE5A (0.63) | CNOT7KMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL10693479 | 0.83 | PDE4A (0.61) | CNOT7KMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL9351786 | 0.79 | PDE4A (0.50) | KMT2AALDH1A1TSHRMAPK1PDE4A | |
| SCHEMBL10695424 | 0.78 | KMT2A (0.51) | CNOT7KMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL1457501 | 0.78 | PDE1A (0.69) | CNOT7KMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL9350760 | 0.78 | PDE4A (0.62) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9351794 | 0.76 | BRD4 (0.71) | CNOT7KMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL27583005 | 0.75 | ALDH1A1 (0.69) | CNOT7ALDH1A1TSHRPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0369744-B1 | Xanthine derivatives, process for their preparation and pharmaceutical compositions | SMITHKLINE BEECHAM PHARMA GMBH (DE) | 1994-09-21 | — | — | EP | disclosed |
| US-5321029-A | Vascular and skin disorders; bronchodilator | BEECHAM-WUELFING GMBH & CO.K.G. (DE) | 1994-06-14 | — | — | US | disclosed |
| EP-0369744-A2 | Xanthine derivatives, process for their preparation and pharmaceutical compositions | SMITHKLINE BEECHAM PHARMA GmbH (DE) | 1990-05-23 | — | — | EP | disclosed |