Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.61 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.61 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.61 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.61 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10697104 | 0.89 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL10696123 | 0.89 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL10695424 | 0.84 | KMT2A (0.51) | KMT2AALDH1A1SMN1; SMN2MEN1HPGD | |
| SCHEMBL9350633 | 0.84 | KMT2A (0.57) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL9350641 | 0.83 | CNOT7 (0.53) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL10694108 | 0.82 | PDE4A (0.91) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL10695543 | 0.82 | PDE4A (0.91) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL7567218 | 0.81 | ALDH1A1 (0.58) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL7564102 | 0.80 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL7564474 | 0.79 | POLB (0.73) | ADORA2BKMT2AALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0260127-A2 | Xanthine derivatives, their preparation and pharmaceutical compositions containing them | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1988-03-16 | — | — | EP | disclosed |