Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.44 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | TNKS | O95271 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10800114 | 0.73 | MAPT (0.65) | LMNAMAPTSMN1; SMN2HDAC3HDAC4 | |
| SCHEMBL7213005 | 0.72 | LMNA (0.52) | LMNAMAPTSMN1; SMN2HDAC3HDAC4 | |
| SCHEMBL869265 | 0.70 | MAPT (0.64) | LMNAMAPTSMN1; SMN2HDAC3HDAC4 | |
| SCHEMBL775716 | 0.70 | MAPT (0.64) | LMNAMAPTSMN1; SMN2HDAC3HDAC4 | |
| SCHEMBL21803794 | 0.70 | MAPT (0.64) | LMNAMAPTSMN1; SMN2HDAC3HDAC4 | |
| SCHEMBL9247555 | 0.70 | MAPT (0.64) | LMNAMAPTSMN1; SMN2HDAC3HDAC4 | |
| SCHEMBL128494 | 0.70 | — | — | |
| SCHEMBL869266 | 0.70 | MAPT (0.64) | LMNAMAPTSMN1; SMN2HDAC3HDAC4 | |
| SCHEMBL126771 | 0.70 | GLA (0.55) | LMNAMAPTSMN1; SMN2HDAC3HDAC4 | |
| SCHEMBL1006098 | 0.70 | GLA (0.55) | LMNAMAPTSMN1; SMN2HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0293220-B1 | Pharmacologically active 2-and 3-substituted (1', 5'-diaryl-3-pyrazolyl)-N-Hydroxypropanamides and method for synthesizing | ORTHO PHARMA CORP (US) | 1994-08-31 | — | — | EP | claimed |
| EP-0293220-A2 | Pharmacologically active 2-and 3-substituted (1', 5'-diaryl-3-pyrazolyl)-N-Hydroxypropanamides and method for synthesizing | ORTHO PHARMACEUTICAL CORPORATION (US) | 1988-11-30 | — | — | EP | claimed |