SCHEMBL9351306

SCHEMBL9351306

O=C(Cl)C[C@H]1CC[C@H](c2ccc([N+](=O)[O-])cc2)CC1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC18A3 Q16572 1/20 0.46
DGAT1 O75907 1/20 0.44
ALDH1A1 P00352 5/20 0.44
TRPV6 Q9H1D0 1/20 0.43
PGR P06401 1/20 0.42
KMT2A Q03164 1/20 0.41
SMN1; SMN2 Q16637 2/20 0.40
NAMPT P43490 1/20 0.40
IDO1 P14902 1/20 0.39
MAPT P10636 2/20 0.39
MAPK1 P28482 1/20 0.39
DPP4 P27487 1/20 0.39
CES1 P23141 1/20 0.39
FAAH O00519 1/20 0.38
ESR1 P03372 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2C9 P11712 1/20 0.38
ESR2 Q92731 1/20 0.38
HPGD P15428 1/20 0.38
CA1 P00915 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9351302 1.00 SLC18A3 (0.46) SLC18A3DGAT1ALDH1A1TRPV6PGR
SCHEMBL3539037 0.87 DGAT1 (0.48) SLC18A3DGAT1ALDH1A1TRPV6PGR
SCHEMBL3539040 0.87 DGAT1 (0.48) SLC18A3DGAT1ALDH1A1TRPV6PGR
SCHEMBL9347444 0.81 TRPV6 (0.47) SLC18A3DGAT1ALDH1A1TRPV6PGR
SCHEMBL9350708 0.81 ESR2 (0.59) SLC18A3ALDH1A1TRPV6PGRNAMPT
SCHEMBL9350713 0.81 ESR2 (0.59) SLC18A3ALDH1A1TRPV6PGRNAMPT
SCHEMBL9347450 0.81 TRPV6 (0.47) SLC18A3DGAT1ALDH1A1TRPV6PGR
SCHEMBL15911925 0.80 SLC18A3 (0.57) SLC18A3ALDH1A1TRPV6PGRNAMPT
SCHEMBL1066991 0.80 SLC18A3 (0.57) SLC18A3ALDH1A1TRPV6PGRNAMPT
SCHEMBL9347459 0.80 NAMPT (0.50) SLC18A3ALDH1A1TRPV6PGRNAMPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0272580-B1 Liquidcrystalline cyclohexylbenzene derivatives their manufacturing and novel nematic admixtures containing same WOJSKOWA AKAD TECH (PL) 1994-08-17 EP disclosed
EP-0272580-A2 Liquidcrystalline cyclohexylbenzene derivatives their manufacturing and novel nematic admixtures containing same Wojskowa Akademia Techniczna im. Jaroslawa Dabrowskiego (PL) 1988-06-29 EP disclosed