Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 3/20 | 0.56 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | CTSV | O60911 | 1/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.48 |
| ▸ | ANO2 | Q9NQ90 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | MPO | P05164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11235113 | 0.80 | ALDH1A1 (0.58) | PKMKDM4EMEN1KMT2AMAPT | |
| SCHEMBL16737204 | 0.79 | CDC25B (0.67) | AKR1C3AKR1C2CTSVCTSLKDM4E | |
| SCHEMBL16737123 | 0.77 | ANO1 (0.58) | AKR1C3AKR1C2CTSVCTSLPOLB | |
| SCHEMBL380803 | 0.76 | HTT (0.60) | AKR1C3AKR1C2PKMCTSVCTSL | |
| SCHEMBL22720115 | 0.75 | MYC (0.65) | AKR1C3AKR1C2CTSVCTSLMEN1 | |
| Hydrochloric Acid SCHEMBL6224359 | 0.75 | HTT (0.58) | AKR1C3AKR1C2PKMCTSVCTSL | |
| Water SCHEMBL10360760 | 0.75 | HTT (0.58) | AKR1C3AKR1C2PKMCTSVCTSL | |
| SCHEMBL16737120 | 0.74 | ANO1 (0.84) | AKR1C3AKR1C2CTSVCTSLPOLB | |
| SCHEMBL16737205 | 0.74 | ANO1 (0.62) | AKR1C3AKR1C2PKMCTSVCTSL | |
| SCHEMBL1671926 | 0.73 | CTSV (0.60) | PKMCTSVCTSLKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992016509-A1 | MULTISUBSTITUTED 1-HYDROXY-9-ACRIDONES WITH ANTICANCER ACTIVITY | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-10-01 | — | — | WO | claimed |
| US-5296602-A | Condensing substituted ortho-halo- or ortho-aminobenzoic acid with meta-halo- or meta-aminoanisole, cyclizing, N-alkylating, de-O-methylating | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1994-03-22 | — | — | US | disclosed |
| WO-1992016509-A1 | MULTISUBSTITUTED 1-HYDROXY-9-ACRIDONES WITH ANTICANCER ACTIVITY | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-10-01 | — | — | WO | disclosed |