Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 0.47 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 10/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 8/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9353001 | 0.94 | HRH1 (0.48) | HRH1SLC6A2SLC6A4 | |
| Fumaric Acid SCHEMBL9352891 | 0.89 | HRH1 (0.50) | HRH1SLC6A2SLC6A4 | |
| Fumaric Acid SCHEMBL9357096 | 0.86 | CHRM2 (0.58) | HRH1SLC6A2SLC6A4 | |
| Fumaric Acid SCHEMBL9353301 | 0.83 | HRH1 (0.47) | HRH1SLC6A2SLC6A4 | |
| Fumaric Acid SCHEMBL9353039 | 0.83 | HRH1 (0.48) | HRH1SLC6A2 | |
| Fumaric Acid SCHEMBL9353458 | 0.81 | HRH1 (0.48) | HRH1SLC6A2SLC6A4THRB | |
| Fumaric Acid SCHEMBL9356759 | 0.80 | SLC6A2 (0.51) | HRH1SLC6A2SLC6A4 | |
| SCHEMBL9353056 | 0.79 | SLC6A2 (0.45) | HRH1SLC6A2SLC6A4 | |
| SCHEMBL9353113 | 0.79 | SLC6A2 (0.50) | HRH1SLC6A2SLC6A4 | |
| Fumaric Acid SCHEMBL9353367 | 0.79 | HRH1 (0.44) | HRH1SLC6A2SLC6A4THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0399414-B1 | Piperidine derivative, method for preparation thereof, and a pharmaceutical composition comprising the same | HOKURIKU PHARMACEUTICAL (JP) | 1994-09-21 | — | — | EP | disclosed |
| US-5153207-A | Antihistamine and antiallergic agent | HOKURIKU PHARMACEUTICAL CO., LTD. (JP) | 1992-10-06 | — | — | US | disclosed |
| EP-0399414-A1 | Piperidine derivative, method for preparation thereof, and a pharmaceutical composition comprising the same | HOKURIKU PHARMACEUTICAL CO., LTD. (JP) | 1990-11-28 | — | — | EP | disclosed |