Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | ACE | P12821 | 1/20 | 0.48 |
| ▸ | SRR | Q9GZT4 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 14/20 | 0.44 |
| ▸ | PPARA | Q07869 | 12/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9354508 | 1.00 | LMNA (0.58) | LMNAACESRRPPARGPPARA | |
| SCHEMBL9354856 | 0.92 | LMNA (0.52) | LMNAACESRRPPARGPPARA | |
| SCHEMBL9354865 | 0.92 | LMNA (0.52) | LMNAACESRRPPARGPPARA | |
| SCHEMBL9354980 | 0.87 | LMNA (0.50) | LMNAPPARGPPARA | |
| SCHEMBL9354988 | 0.87 | LMNA (0.50) | LMNAPPARGPPARA | |
| SCHEMBL7278049 | 0.85 | HSD17B10 (0.58) | ACESRRPPARGPPARA | |
| SCHEMBL9354821 | 0.85 | HSD17B10 (0.58) | ACESRRPPARGPPARA | |
| SCHEMBL9359097 | 0.85 | SRR (0.51) | LMNAACESRRPPARGPPARA | |
| SCHEMBL8909660 | 0.85 | SRR (0.51) | LMNAACESRRPPARGPPARA | |
| SCHEMBL8682156 | 0.85 | SRR (0.51) | LMNAACESRRPPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0300189-B1 | New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1994-11-02 | — | — | EP | disclosed |
| US-5223489-A | Treatment of ypertension and heart failure | UJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-06-29 | — | — | US | disclosed |
| US-5142048-A | Enzyme inhibitor; carbamoyl group-containing acids | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1992-08-25 | — | — | US | disclosed |
| US-4921855-A | New Histidyl amino acid derivatives, and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-05-01 | — | — | US | disclosed |
| EP-0300189-A2 | New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-01-25 | — | — | EP | disclosed |